ArticlePharmacogenetics and genomics2011
Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs.
Article in Pharmacogenetics and genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders.Frontiers in neural circuits · 2022Review
- Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain.Molecules (Basel, Switzerland) · 2021Review
- Methylation Landscape of RUNX3 Promoter Region as a Predictive Marker for Th1/Th2 Imbalance in Bronchiolitis.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Study Design and Rationale for the Mood and Methylation Study: A Platform for Multi-Omics Investigation of Depression in Twins.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2018Article
- Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor.Progress in neuro-psychopharmacology & biological psychiatry · 2018Article
- Inflammatory-linked changes in CpG island methylation of three opioid peptide genes in a rat model for pain.PloS one · 2018Article
- DNA methylation landscape of ocular tissue relative to matched peripheral blood.Scientific reports · 2017Article
- CpG island shore methylation of ZFPM2 is identified in tetralogy of fallot samples.Pediatric research · 2016Article
- Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research.Schizophrenia bulletin · 2016Article
- Review
- MicroRNAs as biomarkers for CNS disease.Frontiers in molecular neuroscience · 2013Review
- Expression of ephrin receptors and ligands in postmortem brains of HIV-infected subjects with and without cognitive impairment.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Article
- Aberrant methylation of gene associated CpG sites occurs in borderline personality disorder.PloS one · 2013Article
- Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Epigenetics and the transition from acute to chronic pain.Pain medicine (Malden, Mass.) · 2012Review
- κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction.Trends in neurosciences · 2012Review
- Chromatin alterations in response to forced swimming underlie increased prodynorphin transcription.Neuroscience · 2012Article
- Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF ) after acute psychosocial stress.Translational psychiatry · 2012Article
- Stress-sensitive neurosignalling in depression: an integrated network biology approach to candidate gene selection for genetic association analysis.Mental illness · 2012Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveDynorphins, the endogenous ligands for the κ opioid receptor, are implicated in neuropsychiatric disorders through modulation of basal and stimuli-induced dopaminergic, glutamatergic, and serotonergic tones. Expression of the prodynorphin gene (PDYN) is critical for rewarding properties of drugs of abuse and stress-induced responses. Epigenetic factors, such as DNA methylation, play an important role in modulation of gene expression.
methodsWe analyzed DNA methylation patterns of three CpG-rich regions of PDYN, a CpG island, and cluster A in the proximal promoter, and cluster B in coding exon 4, by bisulfite sequencing of DNA from the caudate and anterior cingulate cortex from post-mortem brain of 35 individuals (22 HIV seropositive), and in peripheral blood mononuclear cells from 21 of these individuals.
resultsWe found remarkably similar patterns of methylation across CpG sites in these tissues. However, there were tissue-specific differences in methylation levels (P=0.000001) of the CpG island: higher levels in peripheral blood mononuclear cells (82%) than in the brain tissues, the caudate (62%), and the anterior cingulate cortex (44%). But there was higher PDYN expression in the caudate than in the anterior cingulate cortex. In contrast, cluster A near the transcription start site is hypomethylated.
conclusionThis DNA methylation profile of the PDYN gene is typical for primary responsive genes with regulatory elements for both basal and tissue-specific transcription. Our findings provide a rationale for further studies of the role of other epigenetic factors in the regulation of PDYN expression in individuals with psychiatric and neurological disorders.
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