ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2011
Change in hippocampal volume on magnetic resonance imaging and cognitive decline among older depressed and nondepressed subjects in the neurocognitive outcomes of depression in the elderly study.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain-cognition relationships in late-life depression: a systematic review of structural magnetic resonance imaging studies.Translational psychiatry · 2023Pooled it
- Structural MRI-Based Measures of Accelerated Brain Aging do not Moderate the Acute Antidepressant Response in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Trial
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- Accelerated brain aging in prolonged grief disorder of later life: Influence of comorbid depression.Journal of affective disorders · 2026Article
- Late-Onset Depression in an Aging World: A Multidimensional Perspective on Risks, Mechanisms, and Treatment.Geriatrics (Basel, Switzerland) · 2026Review
- Association between depressive symptoms and cognitive impairment among older adults in China: a mediation analysis of proactive health.BMC geriatrics · 2025Article
- Cerebral amyloid-β, glucose metabolism and hippocampal volume in major depression with and without suspected non-Alzheimer pathophysiology (SNAP).Alzheimer's research & therapy · 2025Article
- Cortico-limbic volume abnormalities in late life depression are distinct from β amyloid and white matter pathologies.Molecular psychiatry · 2025Article
- Adiponectin and Inflammatory Marker Levels in the Elderly Patients with Diabetes, Mild Cognitive Impairment and Depressive Symptoms.International journal of molecular sciences · 2024Article
- The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Association of hospitalization with structural brain alterations in patients with affective disorders over nine years.Translational psychiatry · 2023Article
- Cognitive Performance Deficits Are Associated with Clinically Significant Depression Symptoms in Older US Adults.International journal of environmental research and public health · 2023Article
- Executive function deficits and medial temporal lobe atrophy in late-life depression and Alzheimer's disease: a comparative study.Frontiers in psychiatry · 2023Article
- Differences in Odor Identification in Early-Onset and Late-Onset Depression.Brain sciences · 2022Article
- Recognizing Depression in the Elderly: Practical Guidance and Challenges for Clinical Management.Neuropsychiatric disease and treatment · 2022Review
- Crosstalk between Depression and Dementia with Resting-State fMRI Studies and Its Relationship with Cognitive Functioning.Biomedicines · 2021Review
- Frontal-executive and corticolimbic structural brain circuitry in older people with remitted depression, mild cognitive impairment, Alzheimer's dementia, and normal cognition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Predicting conversion to Alzheimer's disease among individual high-risk patients using the Characterizing AD Risk Events index model.CNS neuroscience & therapeutics · 2020Article
- Late life depressive symptoms and cognitive function among older Mexican adults: the past and the present.Aging & mental health · 2020Article
- Linear magnetic resonance imaging measurements of the hippocampal formation differ in young versus old dogs.The Veterinary record · 2019Article
3 more citing papers are in PubMed but not listed here.
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Abstract
introductionprevious studies have linked hippocampal volume change and cognitive decline in older adults with dementia. The authors examined hippocampal volume change and cognitive change in older nondemented adults with and without major depression.
methodsthe sample consisted of 90 depressed individuals and 72 healthy, nondepressed individuals aged 60 years and older who completed at least 2 years of follow-up data. All patients underwent periodic clinical evaluation by a geriatric psychiatrist as well as baseline and 2-year magnetic resonance imaging.
resultsover 2 years, the depressed group showed a greater reduction in left hippocampal volume (normalized for total cerebral volume) compared with the nondepressed group (mean difference = 0.013 ± 0.0059, t = 2.18, df = 160, p <0.0305). The difference remained significant after controlling for age, sex, and baseline normalized left hippocampal volume. The authors also found that hippocampal change from baseline to 2 years was associated with subsequent change in Mini-Mental State Examination score from 2 years to 2½ years (left t = 2.81, df = 66, p = 0.0066; right t = 2.40, df = 66, p = 0.0193) among the depressed group.
conclusionsthese findings add to the literature linking hippocampal volume loss and late-life depression. Depressed patients with hippocampal volume loss are at greater risk of cognitive decline.
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