ArticleNanotechnology2010
Slowing the translocation of double-stranded DNA using a nanopore smaller than the double helix.
Article in Nanotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges.International journal of molecular sciences · 2023Review
- Article
- Spontaneous DNA translocation through a van der Waals heterostructure nanopore for single-molecule detection.Nanoscale advances · 2021Article
- Vibrational Spectra of Nucleotides in the Presence of the Au Cluster Enhancer in MD Simulation of a SERS Sensor.Biosensors · 2021Article
- Entropic Trapping of DNA with a Nanofiltered Nanopore.ACS applied nano materials · 2019Article
- Slowing down DNA translocation velocity using a LiCl salt gradient and nanofiber mesh.European biophysics journal : EBJ · 2019Article
- Fabrication of Subnanometer-Precision Nanopores in Hexagonal Boron Nitride.Scientific reports · 2017Article
- Mechanical Trapping of DNA in a Double-Nanopore System.Nano letters · 2016Article
- Polymer translocation through nano-pores in vibrating thin membranes.Scientific reports · 2016Article
- Integrated solid-state nanopore platform for nanopore fabrication via dielectric breakdown, DNA-speed deceleration and noise reduction.Scientific reports · 2016Article
- Optofluidic devices with integrated solid-state nanopores.Mikrochimica acta · 2016Article
- Article
- Deceleration of single-stranded DNA passing through a nanopore using a nanometre-sized bead structure.Scientific reports · 2015Article
- Article
- Stretching and controlled motion of single-stranded DNA in locally heated solid-state nanopores.ACS nano · 2013Article
- Mechanism of how salt-gradient-induced charges affect the translocation of DNA molecules through a nanopore.Biophysical journal · 2013Article
- Article
- Toward detection of DNA-bound proteins using solid-state nanopores: insights from computer simulations.Electrophoresis · 2012Article
- Ion transport through a graphene nanopore.Nanotechnology · 2012Article
- Single-stranded DNA within nanopores: conformational dynamics and implications for sequencing; a molecular dynamics simulation study.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
It is now possible to slow and trap a single molecule of double-stranded DNA (dsDNA), by stretching it using a nanopore, smaller in diameter than the double helix, in a solid-state membrane. By applying an electric force larger than the threshold for stretching, dsDNA can be impelled through the pore. Once a current blockade associated with a translocating molecule is detected, the electric field in the pore is switched in an interval less than the translocation time to a value below the threshold for stretching. According to molecular dynamics (MD) simulations, this leaves the dsDNA stretched in the pore constriction with the base-pairs tilted, while the B-form canonical structure is preserved outside the pore. In this configuration, the translocation velocity is substantially reduced from 1 bp/10 ns to approximately 1 bp/2 ms in the extreme, potentially facilitating high fidelity reads for sequencing, precise sorting, and high resolution (force) spectroscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.