ArticleThe British journal of psychiatry : the journal of mental science2010
Neurodevelopmental marker for limbic maldevelopment in antisocial personality disorder and psychopathy.
Article in The British journal of psychiatry : the journal of mental science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Is the Psychopathic Brain an Artifact of Coding Bias? A Systematic Review.Frontiers in psychology · 2021Pooled it
- Pooled it
- Neural bases of antisocial behavior: a voxel-based meta-analysis.Social cognitive and affective neuroscience · 2014Pooled it
- Review
- Personality and Psychoneuroimmunology: A Systems Biology Perspective.Methods in molecular biology (Clifton, N.J.) · 2025Review
- The basolateral amygdala to lateral septum circuit is critical for regulating social novelty in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Psychopathic and autistic traits differentially influence the neural mechanisms of social cognition from communication signals.Translational psychiatry · 2022Article
- Cognitive Empathy in Subtypes of Antisocial Individuals.Frontiers in psychiatry · 2021Review
- Conduct Disorder: Biology and Developmental Trajectories.The Psychiatric quarterly · 2020Review
- Recent neuro-imaging findings with respect to conduct disorder, callous-unemotional traits and psychopathy.Current opinion in psychiatry · 2020Review
- Cavum Septum Pellucidum in the General Pediatric Population and Its Relation to Surrounding Brain Structure Volumes, Cognitive Function, and Emotional or Behavioral Problems.AJNR. American journal of neuroradiology · 2019Article
- The relationship between cavum septum pellucidum and psychopathic traits in a large forensic sample.Neuropsychologia · 2018Article
- The Development of Severe and Chronic Violence Among Youth: The Role of Psychopathic Traits and Reward Processing.Child psychiatry and human development · 2017Review
- Abnormal white matter integrity in rapists as indicated by diffusion tensor imaging.BMC neuroscience · 2016Article
- Neural correlates of impulsive aggressive behavior in subjects with a history of alcohol dependence.Behavioral neuroscience · 2015Article
- tPA Deficiency in Mice Leads to Rearrangement in the Cerebrovascular Tree and Cerebroventricular Malformations.Frontiers in cellular neuroscience · 2015Article
- Neurocriminology: implications for the punishment, prediction and prevention of criminal behaviour.Nature reviews. Neuroscience · 2014Review
- The neurobiology of psychopathic traits in youths.Nature reviews. Neuroscience · 2013Review
- The relationship between large cavum septum pellucidum and antisocial behavior, callous-unemotional traits and psychopathy in adolescents.Journal of child psychology and psychiatry, and allied disciplines · 2013Article
- Enlarged cavum septum pellucidum as a neurodevelopmental marker in adolescent-onset opiate dependence.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAntisocial personality disorder and psychopathy have been hypothesised to have a neurodevelopmental basis, but this proposition has not been formally tested.
aimsThis study tests the hypothesis that individuals with cavum septum pellucidum (CSP), a marker of limbic neural maldevelopment, will show higher levels of psychopathy and antisocial personality.
methodCavum septum pellucidum was assessed using anatomical magnetic resonance imaging in a community sample. Those with CSP (n = 19) were compared with those lacking CSP (n = 68) on antisocial personality, psychopathy and criminal offending.
resultsThose with CSP had significantly higher levels of antisocial personality, psychopathy, arrests and convictions compared with controls. The pervasiveness of this association was indicated by the fact that those lacking a diagnosis of antisocial personality disorder, but who were charged or convicted for an offence, had a more extensive CSP than non-antisocial controls. Results could not be attributed to prior trauma exposure, head injury, demographic factors or comorbid psychiatric conditions.
conclusionsOur findings appear to be the first to provide evidence for a neurodevelopmental brain abnormality in those with antisocial personality disorder and psychopathy, and support the hypothesis that early maldevelopment of limbic and septal structures predisposes to the spectrum of antisocial behaviours.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.