ArticleMolecular & cellular proteomics : MCP2011
Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy.
Article in Molecular & cellular proteomics : MCP, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Nuclear Proteome Map of Mouse Heart Chambers.Molecular & cellular proteomics : MCP · 2026Article
- Cardiomyocyte Nuclear Pleomorphism in a Mouse Model of Inherited Hypertrophic Cardiomyopathy.Journal of cardiovascular development and disease · 2025Article
- Proteomics of the heart.Physiological reviews · 2024Review
- CHD4 and SMYD1 repress common transcriptional programs in the developing heart.Development (Cambridge, England) · 2024Article
- SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation.Basic research in cardiology · 2023Article
- Article
- Nucleosome proteostasis and histone turnover.Frontiers in molecular biosciences · 2022Review
- Epigenomes in Cardiovascular Disease.Circulation research · 2018Review
- Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction.Oncotarget · 2018Review
- Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver.Cell metabolism · 2017Article
- The chromatin-binding protein Smyd1 restricts adult mammalian heart growth.American journal of physiology. Heart and circulatory physiology · 2016Article
- The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.Developmental cell · 2016Article
- Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development.Development (Cambridge, England) · 2015Article
- Spatial and temporal dynamics of the cardiac mitochondrial proteome.Expert review of proteomics · 2015Review
- How the proteome packages the genome for cardiovascular development.Proteomics · 2014Review
- TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome.PLoS genetics · 2014Article
- Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes.American journal of physiology. Heart and circulatory physiology · 2013Article
- Nuclear tropomyosin and troponin in striated muscle: new roles in a new locale?Journal of muscle research and cell motility · 2013Review
- Recent advances in cardiovascular proteomics.Journal of proteomics · 2013Review
- Systems proteomics of healthy and diseased chromatin.Methods in molecular biology (Clifton, N.J.) · 2013Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
As host to the genome, the nucleus plays a critical role as modulator of cellular phenotype. To understand the totality of proteins that regulate this organelle, we used proteomics to characterize the components of the cardiac nucleus. Following purification, cardiac nuclei were fractionated into biologically relevant fractions including acid-soluble proteins, chromatin-bound molecules and nucleoplasmic proteins. These distinct subproteomes were characterized by liquid chromatography-tandem MS. We report a cardiac nuclear proteome of 1048 proteins--only 146 of which are shared between the distinct subcompartments of this organelle. Analysis of genomic loci encoding these molecules gives insights into local hotspots for nuclear protein regulation. High mass accuracy and complementary analytical techniques allowed the discrimination of distinct protein isoforms, including 54 total histone variants, 17 of which were distinguished by unique peptide sequences and four of which have never been detected at the protein level. These studies are the first unbiased analysis of cardiac nuclear subcompartments and provide a foundation for exploration of this organelle's proteomes during disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.