ArticleThe Journal of physiology2010
Fast glutamate uptake via EAAT2 shapes the cone-mediated light offset response in bipolar cells.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- An EAAT2b/SLC1A2b-mediated chloride leak current enables rapid cone photoreceptor signalling.Open biology · 2025Article
- Contribution of pannexin channels to afterimage signals in the amphibian retina.American journal of physiology. Cell physiology · 2025Article
- EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods.The Journal of general physiology · 2023Article
- Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse.Nature communications · 2023Article
- Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy.Acta neuropathologica communications · 2023Article
- Eliminating Synaptic Ribbons from Rods and Cones Halves the Releasable Vesicle Pool and Slows Down Replenishment.International journal of molecular sciences · 2022Article
- Contributions of glutamate transporters and CaExperimental eye research · 2019Article
- CaeLife · 2019Article
- Mechanisms, pools, and sites of spontaneous vesicle release at synapses of rod and cone photoreceptors.The European journal of neuroscience · 2016Article
- Glycinergic feedback enhances synaptic gain in the distal retina.The Journal of physiology · 2014Article
- Extrasynaptic glutamate and inhibitory neurotransmission modulate ganglion cell participation during glutamatergic retinal waves.Journal of neurophysiology · 2013Article
- Regulation of synaptic transmission at the photoreceptor terminal: a novel role for the cation-chloride co-transporter NKCC1.The Journal of physiology · 2013Article
- Rapid synaptic vesicle endocytosis in cone photoreceptors of salamander retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The mode of retinal presynaptic inhibition switches with light intensity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Glutamate spillover between mammalian cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Excitatory amino acid transporters (EAATs) are responsible for extracellular glutamate uptake within the retina, and are expressed by retinal neurons and Müller cells. Their role within glutamatergic synapses is not completely understood. In the salamander retina, five distinct EAAT-encoding genes have been cloned, making the amphibian retina an excellent system to study EAAT function. This study focused on sEAAT2, which is expressed in photoreceptor terminals and Off-bipolar cells in two isoforms, sEAAT2A and sEAAT2B. Using whole-cell patch-clamp recording, florescence imaging and antibody labelling methods, we systematically studied the functions of these two isoforms at the synapse between photoreceptors and bipolar cells, both in dark and with photic stimulation. Both sEAAT2A and sEAAT2B were sensitive to dihydrokainic acid (DHKA), a known EAAT2-specific inhibitor. Each isoform of sEAAT2 was found to play a role in tonic glutamate uptake at the cone synapse in darkness. Furthermore, presynaptic sEAAT2A strongly suppressed the rapid, transient glutamate signal from cones following light-offset. This was achieved by quickly binding exocytosed glutamate, which subsequently limited glutamate spillover to adjacent receptors at postsynaptic sites. Since the intensity and duration of photic stimulation determine the magnitude of these cone transient signals, we postulate that presynaptic cone EAATs contribute to the encoding of contrast sensitivity in cone vision.
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