Evidence map›Paper›PMID 20807781›Full record

ArticleMolecular cancer therapeutics2010

Architectonics of phage-liposome nanowebs as optimized photosensitizer vehicles for photodynamic cancer therapy.

Sreeram Kalarical Janardhanan, Shoba Narayan, Gopal Abbineni, Andrew Hayhurst, Chuanbin Mao

Abstract read
In one paragraph

Article in Molecular cancer therapeutics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Enhancement of Photodynamic Cancer Therapy by Physical and Chemical Factors.Angewandte Chemie (International ed. in English) · 2019
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Phage-Enabled Nanomedicine: From Probes to Therapeutics in Precision Medicine.Angewandte Chemie (International ed. in English) · 2017
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sreeram Kalarical JanardhananDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, USA.
Shoba Narayan
Gopal Abbineni
Andrew Hayhurst
Chuanbin Mao

Funding

Phage-inspired nanoparticles with genetically tunable target-specificityR01HL092526 · NHLBI · UNIVERSITY OF OKLAHOMA · PI MAO, CHUANBIN · 2009 to 2010
$806k
Phage-Mimetic Nanorods for Targeted Breast Cancer TreatmentR21EB009909 · NIBIB · UNIVERSITY OF OKLAHOMA · PI MAO, CHUANBIN · 2009 to 2010
$399k
Bone-seeking and cell-targeting non-viral vectors for BMP-2 gene deliveryR03AR056848 · NIAMS · UNIVERSITY OF OKLAHOMA · PI MAO, CHUANBIN · 2009 to 2011
$222k
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR012087 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI VANDEBERG, JOHN L · 1996 to 1996
–
NCRR NIH HHS C06 RR012087NCRR NIH HHS C06RR12087NHLBI NIH HHS R01 HL092526NIAMS NIH HHS R03 AR056848NIBIB NIH HHS 1R21EB009909-01A1NIBIB NIH HHS R21 EB009909
6 · The paper itself

Abstract

Filamentous M13 phage can be engineered to display cancer cell-targeting or tumor-homing peptides through phage display. It would be highly desirable if the tumor-targeting phage can also carry anticancer drugs to deliver them to the cancer cells. We studied the evolution of structures of the complexes between anionic filamentous M13 phage and cationic serum-stable liposomes that encapsulate the monomeric photosensitizer zinc naphthalocyanine. At specific phage-liposome ratios, multiple phage nanofibers and liposomes are interwoven into a "nanoweb." The chemical and biological properties of the phage-liposome nanoweb were evaluated for possible application in drug delivery. This study highlights the ability of phage-liposome nanowebs to serve as efficient carriers in the transport of photosensitizers to cancer cells.

Indexed as

Bacteriophage M13Breast NeoplasmsCell Line, TumorDrug Delivery SystemsFemaleHumansLiposomesNanostructuresPeptide LibraryPhotochemotherapyPhotosensitizing AgentsLiposomesPeptide LibraryPhotosensitizing Agents

Identifiers

PMID20807781
PMCPMC2937092

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.