ArticleThe Journal of endocrinology2010
In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets.
Article in The Journal of endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Comparative β-cell development: insights from Rodents, humans and induced pluripotent stem cell models.Stem cell research & therapy · 2025Review
- Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors.Stem cell research & therapy · 2018Article
- Consequences of Rab GTPase dysfunction in genetic or acquired human diseases.Small GTPases · 2018Review
- Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes.Diabetologia · 2015Article
- Article
- Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.PloS one · 2014Article
- Article
- Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.Nature genetics · 2013Article
- Lineage determinants in early endocrine development.Seminars in cell & developmental biology · 2012Review
- The stress of starvation: glucocorticoid restraint of beta cell development.Diabetologia · 2011Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Neurogenin 3 (NGN3) commits pancreatic progenitors to an islet cell fate. We have induced NGN3 expression and identified upregulation of the gene encoding the Ras-associated small molecular mass GTP-binding protein, RAB3B. RAB3B localised to the cytoplasm of human β-cells, both during the foetal period and post natally. Genes encoding alternative RAB3 proteins and RAB27A were unaltered by NGN3 expression and in human adult islets their transcripts were many fold less prevalent than those of RAB3B. The regulation of insulin exocytosis in rodent β-cells and responsiveness to incretins are reliant on Rab family members, notably Rab3a and Rab27a, but not Rab3b. Our results support an important inter-species difference in regulating insulin exocytosis where RAB3B is the most expressed isoform in human islets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.