Evidence map›Paper›PMID 20807600›Full record

ReviewAdvances in genetics2010

MR molecular imaging of tumor vasculature and vascular targets.

Arvind P Pathak, Marie-France Penet, Zaver M Bhujwalla

Abstract readReview
In one paragraph

Review in Advances in genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Exoscope-based videocapillaroscopy system forBiomedical optics express · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Molecular MRI differentiation of VEGF receptor-2 levels in C6 and RG2 glioma models.American journal of nuclear medicine and molecular imaging · 2013
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. MRI of metastasis-permissive microenvironments.Future oncology (London, England) · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Arvind P PathakJHU ICMIC Program, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Marie-France Penet
Zaver M Bhujwalla

Funding

Theranostic Imaging of Metastatic Prostate CancerP50CA103175 · NCI · JOHNS HOPKINS UNIVERSITY · PI BARKER, PETER B · 2003 to 2015
$17.9M
Predictive experiment-based multiscale models of the tumor immune microenvironment and immunotherapy in breast cancerR01CA138264 · NCI · JOHNS HOPKINS UNIVERSITY · PI POPEL, ALEKSANDER S. · 2009 to 2023
$8.1M
HOSTILE ENVIRONMENTS PROMOTE INVASION AND METATASISR01CA082337 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 1999 to 2024
$5.1M
FUNTIONAL IMAGING OF THE METASTATIC PHENOTYPER01CA073850 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 1997 to 2014
$3.5M
Imaging Hypoxia and Cancer Stem CellsR01CA136576 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 2009 to 2017
$2.4M
Image-guided Prodrug and siRNA Targeting of CancerR01CA138515 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 2009 to 2013
$1.7M
A LECTIN-CONTRAST AGENT FOR MULTIMODALITY MOLECULAR IMAGING OF TUMOR ANGIOGENESISR21CA128793 · NCI · JOHNS HOPKINS UNIVERSITY · PI PATHAK, ARVIND P · 2008 to 2009
$406k
Imaging Permissive Microenvironmental Niches for Cancer Stem CellsR21CA133600 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 2009 to 2010
$397k
Molecular Imaging of Cancer CachexiaR21CA140904 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 2009 to 2010
$397k
NCI NIH HHS P50 CA103175NCI NIH HHS R01 CA073850NCI NIH HHS R01 CA082337NCI NIH HHS R01 CA136576NCI NIH HHS R01 CA138264NCI NIH HHS R01 CA138515NCI NIH HHS R01 CA73850NCI NIH HHS R01 CA82337NCI NIH HHS R21 CA128793NCI NIH HHS R21 CA133600NCI NIH HHS R21 CA140904PHS HHS KG090640
6 · The paper itself

Abstract

Tumor angiogenesis and the ability of cancer cells to induce neovasculature continue to be a fascinating area of research. As the delivery network that provides substrates and nutrients, as well as chemotherapeutic agents to cancer cells, but allows cancer cells to disseminate, the tumor vasculature is richly primed with targets and mechanisms that can be exploited for cancer cure or control. The spatial and temporal heterogeneity of tumor vasculature, and the heterogeneity of response to targeting, make noninvasive imaging essential for understanding the mechanisms of tumor angiogenesis, tracking vascular targeting, and detecting the efficacy of antiangiogenic therapies. With its noninvasive characteristics, exquisite spatial resolution and range of applications, magnetic resonance imaging (MRI) techniques have provided a wealth of functional and molecular information on tumor vasculature in applications spanning from "bench to bedside". The integration of molecular biology and chemistry to design novel imaging probes ensures the continued evolution of the molecular capabilities of MRI. In this review, we have focused on developments in the characterization of tumor vasculature with functional and molecular MRI.

Indexed as

Blood VesselsContrast MediaHumansMagnetic Resonance ImagingMolecular ImagingMolecular WeightNeovascularization, PathologicContrast Media

Identifiers

PMID20807600
PMCPMC4921063

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.