ArticleHormones and behavior2010
Activation of ERα is necessary for estradiol's anorexigenic effect in female rats.
Article in Hormones and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- An exploratory microarray analysis of estrogen-mediated gene expression in central pathways that control energy balance in female rats (Rattus norvegicus).BMC research notes · 2026Article
- Sex differences and sex-specific regulation of motivated behavior by Melanin-concentrating hormone: a short review.Biology of sex differences · 2024Review
- AstrocyticCannabis and cannabinoid research · 2024Article
- Inhibition of Estradiol Signaling in the Basolateral Amygdala Impairs Extinction Memory Recall for Heroin-Conditioned Cues in a Sex-Specific Manner.Neuroendocrinology · 2024Article
- Regulation of sex differences in risk-based decision making by gonadal hormones: Insights from rodent models.Behavioural processes · 2022Review
- Relationship Between Circulating Metabolic Hormones and Their Central Receptors During Ovariectomy-Induced Weight Gain in Rats.Frontiers in physiology · 2021Article
- Sexes on the brain: Sex as multiple biological variables in the neuronal control of feeding.Biochimica et biophysica acta. Molecular basis of disease · 2020Review
- Estradiol and high fat diet associate with changes in gut microbiota in female ob/ob mice.Scientific reports · 2019Article
- Gonadal hormones affect alcohol drinking, but not cue+yohimbine-induced alcohol seeking, in male and female rats.Physiology & behavior · 2019Article
- Anorexigenic effects of estradiol in the medial preoptic area occur through membrane-associated estrogen receptors and metabotropic glutamate receptors.Hormones and behavior · 2019Article
- Notoginsenoside RRSC advances · 2018Article
- Prior weight loss exacerbates the biological drive to gain weight after the loss of ovarian function.Physiological reports · 2017Article
- Effects of chronic exposure to triclosan on reproductive and thyroid endpoints in the adult Wistar female rat.Journal of toxicology and environmental health. Part A · 2017Article
- Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals.Frontiers in endocrinology · 2017Review
- Effects of aging on stress-related responses of serotonergic neurons in the dorsal raphe nucleus of male rats.Neurobiology of stress · 2016Article
- The ERα-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice.Endocrinology · 2015Article
- Multiple estrogen receptor subtypes influence ingestive behavior in female rodents.Physiology & behavior · 2015Review
- Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells.Molecular and cellular endocrinology · 2015Article
- Effects of postnatal estrogen manipulations on juvenile alloparental behavior.Hormones and behavior · 2015Article
- Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice.Psychopharmacology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
While there is considerable evidence that the ovarian hormone estradiol reduces food intake in female rats, it is unclear which estrogen receptor (ER) subtype, ERα or ERβ, mediates this effect. While several studies have demonstrated that activation of ERα, but not ERβ, is sufficient to reduce food intake in ovariectomized (OVX) rats, there are limited data regarding which receptor subtype is necessary. Here we used the selective ERα and ERß antagonists, MPrP and PHTPP, respectively, to investigate this question. We found that antagonism of ERα, but not ERβ, prevented the decrease in food intake following acute administration of estradiol in OVX rats. In addition, antagonism of ERα prevented the estrous-related, phasic reduction in food intake that occurs in response to the rise in circulating levels of estradiol in cycling rats. We conclude that activation of ERα is necessary for the anorexigenic effects of exogenous and endogenous estradiol in female rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.