ReviewDiscovery medicine2010
The genetics of systemic sclerosis.
Review in Discovery medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Genetic Interactions Affect Lung Function in Patients with Systemic Sclerosis.G3 (Bethesda, Md.) · 2020Article
- Kidney involvement in systemic sclerosis: From pathogenesis to treatment.Journal of scleroderma and related disorders · 2018Review
- Gastrointestinal Manifestations of Systemic Sclerosis.Rheumatology (Sunnyvale, Calif.) · 2018Article
- Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations.PloS one · 2018Article
- Association of a rare NOTCH4 coding variant with systemic sclerosis: a family-based whole exome sequencing study.BMC musculoskeletal disorders · 2016Article
- Article
- Current perspectives on the immunopathogenesis of systemic sclerosis.ImmunoTargets and therapy · 2016Review
- Genetics, Epigenetics, and Genomics of Systemic Sclerosis.Rheumatic diseases clinics of North America · 2015Review
- DNA methylation similarities in genes of black South Africans with systemic lupus erythematosus and systemic sclerosis.Journal of biomedical science · 2015Article
- Pathogenesis of Systemic Sclerosis.Frontiers in immunology · 2015Review
- Genetics of Interstitial Lung Disease: Vol de Nuit (Night Flight).Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2015Review
- Genetics of systemic sclerosis: an update.Current rheumatology reports · 2012Review
- Targeting STAT4 in systemic sclerosis: a promising new direction.Expert review of clinical immunology · 2011Article
- Vascular involvement in systemic sclerosis (scleroderma).Journal of inflammation research · 2011Article
- Case Report: Systemic Sclerosis After Covid-19 Infection.Frontiers in immunologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Systemic sclerosis (SSc, scleroderma) is an autoimmune disease clinically characterized by progressive fibrosis in the skin and internal organs. While the pathogenesis of SSc is not completely understood, familial studies and genetic studies suggest that SSc is a complex polygenic disease. In the current review, we will discuss recent studies investigating genetic susceptibility to SSc. Candidate gene studies have identified critical immunoregulatory genes and gene regions including BANK1, FAM167A-BLK, IL23R, IRF5, STAT4, TBX21, and TNFSF4 as susceptibility genes for the development of SSc. More recently a genome-wide association study has been performed and identified CD247 (CD3-zeta) as a novel genetic risk factor for the susceptibility to SSc. Together these genetic association studies have substantially advanced our understanding of SSc pathogenesis and form the foundation for future studies seeking to understand the complexities of SSc.
Indexed as
Identifiers
20807474PMC3803145W105605248What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.