ArticleThe journal of sexual medicine2010
Erectile dysfunction in young non-obese type II diabetic Goto-Kakizaki rats is associated with decreased eNOS phosphorylation at Ser1177.
Article in The journal of sexual medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 33 citations in OpenAlex.
- Animal models in the study of diabetic erectile dysfunction: mechanisms and applications.Frontiers in endocrinology · 2025Review
- Role of Glucose-Lowering Medications in Erectile Dysfunction.Journal of clinical medicine · 2021Review
- Constitutive NOS uncoupling and NADPH oxidase upregulation in the penis of type 2 diabetic men with erectile dysfunction.Andrology · 2017Article
- Penile constitutive nitric oxide synthase expression in rats exposed to unpredictable chronic mild stress: role of inflammation.International journal of impotence research · 2017Article
- A novel experimental model of erectile dysfunction in rats with heart failure using volume overload.PloS one · 2017Article
- Molecular mechanisms associated with diabetic endothelial-erectile dysfunction.Nature reviews. Urology · 2016Review
- Article
- The impact of diabetes mellitus on penile length in men undergoing inflatable penile prosthesis implantation.Turkish journal of urology · 2013Article
- Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction.The journal of sexual medicine · 2013Article
- Erectile dysfunction precedes coronary artery endothelial dysfunction in rats fed a high-fat, high-sucrose, Western pattern diet.The journal of sexual medicine · 2013Article
- The use of animal models in diabetes research.British journal of pharmacology · 2012Article
- Article
- Internal pudendal artery from type 2 diabetic female rats demonstrate elevated endothelin-1-mediated constriction.The journal of sexual medicine · 2011Article
- Penile alterations at early stage of type 1 diabetes in rats.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- EXPERIMENTAL INDUCTION OF TYPE 2 DIABETES MELLITUS AND THE EFFICIENCY OF BARIATRIC SURGERY IN ITS REVERSAL IN RATS.Acta endocrinologica (Bucharest, Romania : 2005)Article
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7 authors at 2 institutions in 2 countries.
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Abstract
introductionDiabetes mellitus (DM) is a risk factor for erectile dysfunction (ED). Although type 2 DM is responsible for 90-95% diabetes cases, type 1 DM experimental models are commonly used to study diabetes-associated ED.
aimGoto-Kakizaki (GK) rat model is relevant to ED studies since the great majority of patients with type 2 diabetes display mild deficits in glucose-stimulated insulin secretion, insulin resistance, and hyperglycemia. We hypothesized that GK rats display ED which is associated with decreased nitric oxide (NO) bioavailability.
methodsWistar and GK rats were used at 10 and 18 weeks of age. Changes in the ratio of intracavernosal pressure/mean arterial pressure (ICP/MAP) after electrical stimulation of cavernosal nerve were determined in vivo. Cavernosal contractility was induced by electrical field stimulation (EFS) and phenylephrine (PE). In addition, nonadrenergic-noncholinergic (NANC)- and sodium nitroprusside (SNP)-induced relaxation were determined. Cavernosal neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS) mRNA and protein expression were also measured.
main outcome measureGK diabetic rats display ED associated with decreased cavernosal expression of eNOS protein.
resultsGK rats at 10 and 18 weeks demonstrated impaired erectile function represented by decreased ICP/MAP responses. Ten-week-old GK animals displayed increased PE responses and no changes in EFS-induced contraction. Conversely, contractile responses to EFS and PE were decreased in cavernosal tissue from GK rats at 18 weeks of age. Moreover, GK rats at 18 weeks of age displayed increased NANC-mediated relaxation, but not to SNP. In addition, ED was associated with decreased eNOS protein expression at both ages.
conclusionAlthough GK rats display ED, they exhibit changes in cavernosal reactivity that would facilitate erectile responses. These results are in contrast to those described in other experimental diabetes models. This may be due to compensatory mechanisms in cavernosal tissue to overcome restricted pre-penile arterial blood supply or impaired veno-occlusive mechanisms.
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