ArticleMolecular microbiology2010
Integrating conjugative elements of the SXT/R391 family trigger the excision and drive the mobilization of a new class of Vibrio genomic islands.
Article in Molecular microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59 citing papers in PubMed, 96 citations in OpenAlex.
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- Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes.Molecular biology and evolution · 2026Article
- Interactions and evolutionary relationships among bacterial mobile genetic elements.Nature reviews. Microbiology · 2025Review
- Genomic Island-Encoded Diguanylate Cyclase fromMicroorganisms · 2023Article
- Conjugative transfer of streptococcal prophages harboring antibiotic resistance and virulence genes.The ISME journal · 2023Article
- Origins of transfer establish networks of functional dependencies for plasmid transfer by conjugation.Nucleic acids research · 2023Article
- Breaking the ICE: an easy workflow for identifying and analyzing integrative and conjugative elements in bacterial genomes.Functional & integrative genomics · 2022Article
- Mobile genetic elements used by competing coral microbial populations increase genomic plasticity.The ISME journal · 2022Article
- Bioinformatic and experimental characterization of SEN1998: a conserved gene carried by the Enterobacteriaceae-associated ROD21-like family of genomic islands.Scientific reports · 2022Article
- Population genomics of the food-borne pathogenMicrobial genomics · 2022Article
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- Prevalence and mobility of integrative and conjugative elements within aFrontiers in microbiology · 2022Article
- Genomic islands targeting dusA in Vibrio species are distantly related to Salmonella Genomic Island 1 and mobilizable by IncC conjugative plasmids.PLoS genetics · 2021Article
- ICEHpsaHPS7, a Novel Multiple Drug Resistance Integrative Conjugative Element inAntimicrobial agents and chemotherapy · 2021Article
- Horizontal Transfer of DifferentFrontiers in microbiology · 2021Article
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- Antibiotic Susceptibility Testing (AST) Reports: A Basis for Environmental/Epidemiological Surveillance and Infection Control Amongst EnvironmentalInternational journal of environmental research and public health · 2020Article
- Genomic Analysis of SXT/R391 Integrative Conjugative Elements FromFrontiers in microbiology · 2020Article
- ICEberg 2.0: an updated database of bacterial integrative and conjugative elements.Nucleic acids research · 2019Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vibrios and enterobacteria lateral gene transfer is often facilitated by integrating conjugative elements (ICEs) of the SXT/R391 family. SXT/R391 ICEs integrate by site-specific recombination into prfC and transfer by conjugation, a process that is initiated at a specific locus called the origin of transfer (oriT(SXT) ). We identified genomic islands (GIs) harbouring a sequence that shares >63% identity with oriT(SXT) in three species of Vibrio. Unlike SXT/R391 ICEs, these GIs are integrated into a gene coding for a putative stress-induced protein and do not appear to carry any gene coding for a conjugative machinery or for mobilization proteins. Our results show that SXT/R391 ICEs trigger the excision and mediate the conjugative transfer in trans of the three Vibrio GIs at high frequency. GIs' excision is independent of the ICE-encoded recombinase and is controlled by the ICE-encoded transcriptional activator SetCD, which is expressed during the host SOS response. Both mobI and traI, two ICE-borne genes involved in oriT recognition, are essential for GIs' transfer. We also found that SXT/R391 ICEs mobilize in trans over 1 Mb of chromosomal DNA located 5' of the GIs' integration site. Together these results support a novel mechanism of mobilization of GIs by ICEs of the SXT/R391 family.
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