ArticleTissue engineering. Part A2011
Magnetic resonance studies of macromolecular content in engineered cartilage treated with pulsed low-intensity ultrasound.
Article in Tissue engineering. Part A, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Quantitative MRI methods for the assessment of structure, composition, and function of musculoskeletal tissues in basic research and preclinical applications.Magma (New York, N.Y.) · 2024Review
- Near-Infrared Spectroscopy Predicts Compositional and Mechanical Properties of Hyaluronic Acid-Based Engineered Cartilage Constructs.Tissue engineering. Part A · 2018Article
- Review
- Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties.The Analyst · 2017Article
- Nondestructive Assessment of Engineered Cartilage Composition by Near Infrared Spectroscopy.Annals of biomedical engineering · 2016Article
- Monitoring cartilage tissue engineering using magnetic resonance spectroscopy, imaging, and elastography.Tissue engineering. Part B, Reviews · 2013Review
- Imaging challenges in biomaterials and tissue engineering.Biomaterials · 2013Article
- Clinical outcome of autologous chondrocyte implantation is correlated with infrared spectroscopic imaging-derived parameters.Osteoarthritis and cartilage · 2012Article
- Characterization of engineered cartilage constructs using multiexponential T₂ relaxation analysis and support vector regression.Tissue engineering. Part C, Methods · 2012Article
- Multivariate analysis of cartilage degradation using the support vector machine algorithm.Magnetic resonance in medicine · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Noninvasive monitoring of matrix development in tissue-engineered cartilage constructs would permit ongoing assessment with the ability to modify culture conditions during development to optimize tissue characteristics. In this study, chondrocytes seeded in a collagen hydrogel were exposed for 20 min/day to pulsed low-intensity ultrasound (PLIUS) at 30 mWcm(-2) and cultured for up to 5 weeks. Biochemical assays, histology, immunohistochemistry, Fourier transform infrared spectroscopy, and magnetic resonance imaging (MRI) were performed at weeks 3 and 5 after initiation of growth. The noninvasive MRI measurements were correlated with those from the invasive studies. In particular, MRI transverse relaxation time (T2) and magnetization transfer rate (k(m)) correlated with macromolecular content, which was increased by application of PLIUS. This indicates the sensitivity of MR techniques to PLIUS-induced changes in matrix development, and highlights the potential for noninvasive assessment of the efficacy of anabolic interventions for engineered tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.