Searching for new strategies for the pharmacological treatment of chronic pain.

Daniela Salvemini

Open access · greenAbstract read

In one paragraph

Article in Missouri medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 58% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 2 countries.

Daniela SalveminiDepartment of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA. salvemd@slu.edu

Saint Louis University · US

Funding

Role of peroxynitrite in morphine hyperalgesia and toleranceR01DA024074 · NIDA · SAINT LOUIS UNIVERSITY · PI SALVEMINI, DANIELA · 2008 to 2012

$1.7M

Targeting the relief of chronic pain with orally active peroxynitrite decompositiRC1AR058231 · NIAMS · SOUTHERN ILLINOIS UNIV AT EDWARDSVILLE · PI NEUMANN, WILLIAM, SALVEMINI, DANIELA · 2009 to 2010

$974k

CCR NIH HHS 1RC1 AR058231NIAMS NIH HHS RC1 AR058231NIDA NIH HHS R01 DA024074

6 · The paper itself

Abstract

Chronic pain is poorly managed and represents a huge unmet medical need that affects humans globally. The traditional multifaceted drug regimens for controlling chronic pain are marginally effective, produce highly variable results and display for the most parts unacceptable side effects. Research efforts over the last decade have identified peroxynitrite (PN) as a critical signaling molecule in the development of pain. Targeting PN is a novel evidence-based approach to develop novel therapeutics for managing chronic pain.

Indexed as

AntioxidantsChronic DiseaseFree Radical ScavengersHumansOxidative StressPainPeroxynitrous AcidReceptors, N-Methyl-D-AspartateAntioxidantsFree Radical ScavengersPeroxynitrous AcidReceptors, N-Methyl-D-Aspartate

Identifiers

PMID20806838

PMCPMC6188358

OpenAlexW2426530573

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.