ArticleMagnetic resonance in medicine2010
Manganese-enhanced MRI of salivary glands and head and neck tumors in living subjects.
Article in Magnetic resonance in medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Manganese-Enhanced MRI of the Brain in Healthy Volunteers.AJNR. American journal of neuroradiology · 2019Article
- Manganese-Enhanced Magnetic Resonance Imaging for Detection and Characterization of Colorectal Cancers.Tomography (Ann Arbor, Mich.) · 2018Article
- Biodistribution and PET Imaging of pharmacokinetics of manganese in mice using Manganese-52.PloS one · 2017Article
- Manganese-enhanced MRI for the detection of metastatic potential in colorectal cancer.European radiology experimental · 2017Article
- In vivo MEMRI characterization of brain metastases using a 3D Look-Locker T1-mapping sequence.Scientific reports · 2016Article
- Uptake and retention of manganese contrast agents for PET and MRI in the rodent brain.Contrast media & molecular imaging · 2016Article
- Self-organized MnJournal of materials chemistry. B · 2014Article
- Theranostic effect of serial manganese-enhanced magnetic resonance imaging of human embryonic stem cell derived teratoma.Magnetic resonance in medicine · 2012Article
- Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Manganese-enhanced MRI has previously been used for visualization of brain architecture and functional mapping of neural pathways. The present work investigated the potential of manganese-enhanced MRI for noninvasive imaging of salivary glands in living subjects. Marked shortening of T(1) was observed in salivary glands of naïve mice (n = 5) 24-48 h after systemic administration of MnCl(2) (0.4 mmol/kg, intraperitoneally). Three-dimensional MR microscopy confirmed selective contrast enhancement of salivary gland tissues post-MnCl(2) injection. Ectopic and orthotopic head and neck tumor xenografts also showed an increase in R(1) at 24 h following MnCl(2) injection (0.2 mmol/kg, intraperitoneally). However, tumor enhancement was minimal compared to salivary gland tissue. Salivary gland R(1) values were lower in mice bearing orthotopic head and neck tumors compared to naïve mice. These results demonstrate, for the first time, the usefulness of manganese-enhanced MRI in the visualization of salivary glands and head and neck tumors in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.