ArticleMagnetic resonance in medicine2010
Compartment-specific enhancement of white matter and nerve ex vivo using chromium.
Article in Magnetic resonance in medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Assessment of precision and accuracy of brain white matter microstructure using combined diffusion MRI and relaxometry.Human brain mapping · 2024Article
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- Multidimensional correlation MRI.NMR in biomedicine · 2020Article
- Towards unconstrained compartment modeling in white matter using diffusion-relaxation MRI with tensor-valued diffusion encoding.Magnetic resonance in medicine · 2020Article
- Retaining information from multidimensional correlation MRI using a spectral regions of interest generator.Scientific reports · 2020Article
- Measuring intra-axonal TMagnetic resonance in medicine · 2019Article
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- Optimization of selective inversion recovery magnetization transfer imaging for macromolecular content mapping in the human brain.Magnetic resonance in medicine · 2018Article
- Characterizing intra-axonal water diffusion with direction-averaged triple diffusion encoding MRI.NMR in biomedicine · 2018Article
- Diffusional kurtosis imaging and white matter microstructure modeling in a clinical study of major depressive disorder.NMR in biomedicine · 2018Article
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- Simulations on the influence of myelin water in diffusion-weighted imaging.Physics in medicine and biology · 2016Article
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- Long-term effects of neonatal hypoxia-ischemia on structural and physiological integrity of the eye and visual pathway by multimodal MRI.Investigative ophthalmology & visual science · 2014Article
- Microstructural origins of gadolinium-enhanced susceptibility contrast and anisotropy.Magnetic resonance in medicine · 2014Article
- Characterizing inter-compartmental water exchange in myelinated tissue using relaxation exchange spectroscopy.Magnetic resonance in medicine · 2013Article
- Micro-compartment specific T2* relaxation in the brain.NeuroImage · 2013Article
- Effect of intercompartmental water exchange on the apparent myelin water fraction in multiexponential T2 measurements of rat spinal cord.Magnetic resonance in medicine · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Chromium--Cr(VI) in the form of potassium dichromate--has been shown to specifically enhance white matter signal. The proposed mechanism for this enhancement is reduction of diamagnetic Cr(VI) to paramagnetic chromium species by oxidizable myelin lipids. The purpose of the study herein was to better understand the microanatomical basis of this enhancement (i.e., the relative enhancement of myelin, intra-axonal, and extra-axonal water). Toward this end, integrated T(1)-T(2) measurements were performed in potassium dichromate loaded (hereafter referred to as chromated) rat brains, rat optic nerve samples, and frog sciatic nerve samples ex vivo. In control optic nerve and white matter, two T(1)-T(2) components were resolved, representing myelin and nonmyelin water (intra- and extra-axonal water). Following chromation, three T(1)-T(2) components were resolved in these same tissues. Results from similar measurements in sciatic nerve-all three components are resolvable in control and chromated samples-and quantitative histologic analysis suggest that this additional T(1)-T(2) component is due to a splitting of the nonmyelin water component into intra- and extra-axonal water components. This compartment-specific enhancement may provide unique contrast for MR histology, as well as allow one to probe the compartmental basis of various contrast mechanisms in neural tissue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.