ArticleMagnetic resonance in medicine2010
Fast human brain magnetic resonance responses associated with epileptiform spikes.
Article in Magnetic resonance in medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Functional conductivity imaging: quantitative mapping of brain activity.Physical and engineering sciences in medicine · 2024Article
- Can MRI Be Used as a Sensor to Record Neural Activity?Sensors (Basel, Switzerland) · 2023Review
- Toward direct MRI of neuro-electro-magnetic oscillations in the human brain.Magnetic resonance in medicine · 2019Article
- Magnetic resonance imaging of ionic currents in solution: the effect of magnetohydrodynamic flow.Magnetic resonance in medicine · 2015Article
- Octopus visual system: a functional MRI model for detecting neuronal electric currents without a blood-oxygen-level-dependent confound.Magnetic resonance in medicine · 2014Article
- The movement of a nerve in a magnetic field: application to MRI Lorentz effect imaging.Medical & biological engineering & computing · 2014Article
- Article
- Is it possible to detect dendrite currents using presently available magnetic resonance imaging techniques?Medical & biological engineering & computing · 2012Article
- An empirical investigation of motion effects in eMRI of interictal epileptiform spikes.Magnetic resonance imaging · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Neuronal currents produce local electromagnetic fields that can potentially modulate the phase of the magnetic resonance signal and thus provide a contrast mechanism tightly linked to neuronal activity. Previous work has demonstrated the feasibility of direct MRI of neuronal activity in phantoms and cell culture, but in vivo efforts have yielded inconclusive, conflicting results. The likelihood of detecting and validating such signals can be increased with (i) fast gradient-echo echo-planar imaging, with acquisition rates sufficient to resolve neuronal activity, (ii) subjects with epilepsy, who frequently experience stereotypical electromagnetic discharges between seizures, expressed as brief, localized, high-amplitude spikes (interictal discharges), and (iii) concurrent electroencephalography. This work demonstrates that both MR magnitude and phase show large-amplitude changes concurrent with electroencephalography spikes. We found a temporal derivative relationship between MR phase and scalp electroencephalography, suggesting that the MR phase changes may be tightly linked to local cerebral activity. We refer to this manner of MR acquisition, designed explicitly to track the electroencephalography, as encephalographic MRI (eMRI). Potential extension of this technique into a general purpose functional neuroimaging tool requires further study of the MR signal changes accompanying lower amplitude neuronal activity than those discussed here.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.