ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 5 citations in OpenAlex.
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- Transcriptional control of visual neural circuit development by GS homeobox 1.PLoS genetics · 2024Article
- Cohesin: an emerging master regulator at the heart of cardiac development.Molecular biology of the cell · 2023Article
- Regulation of axon pathfinding by astroglia across genetic model organisms.Frontiers in cellular neuroscience · 2023Review
- Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development.Cell death discovery · 2022Article
- Transposable element-derived sequences in vertebrate development.Mobile DNA · 2021Review
- Integrative analyses prioritize GNL3 as a risk gene for bipolar disorder.Molecular psychiatry · 2020Article
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- QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis.PloS one · 2019Article
- Detection and quantification of a KIF11 mosaicism in a subject presenting familial exudative vitreoretinopathy with microcephaly.European journal of human genetics : EJHG · 2018Article
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- Overexpression of kynurenic acid and 3-hydroxyanthranilic acid after rat traumatic brain injury.European journal of histochemistry : EJH · 2018Article
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- The neurological toxicity of heavy metals: A fish perspective.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2018Review
- Expansion microscopy of zebrafish for neuroscience and developmental biology studies.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Myosin phosphatase Fine-tunes Zebrafish Motoneuron Position during Axonogenesis.PLoS genetics · 2016Article
- Review
- Article
- Regeneration of Zebrafish CNS: Adult Neurogenesis.Neural plasticity · 2016Review
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
The formation of the central nervous system depends on the coordinated development of neural and glial cell types that arise from a common precursor. Using an existing group of zebrafish mutants generated by viral insertion, we performed a "shelf-screen" to identify genes necessary for astroglial development and axon scaffold formation. We screened 274 of 315 viral insertion lines using antibodies that label axons (anti-Acetylated Tubulin) and astroglia (anti-Gfap) and identified 25 mutants with defects in gliogenesis, glial patterning, neurogenesis, and axon guidance. We also identified a novel class of mutants affecting radial glial cell numbers. Defects in astroglial patterning were always associated with axon defects, supporting an important role for axon-glial interactions during axon scaffold development. The genes disrupted in these viral lines have all been identified, providing a powerful new resource for the study of axon guidance, glio- and neurogenesis, and neuron-glial interactions during development of the vertebrate CNS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.