Evidence map›Paper›PMID 20806052›Full record

ArticleFuture neurology2010

Insights into neurogenesis and aging: potential therapy for degenerative disease?

Robert A Marr, Rosanne M Thomas, Daniel A Peterson

Abstract read
In one paragraph

Article in Future neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
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  5. Article
  6. Review
  7. Article
  8. Water-soluble lipophilic MR contrast agents for cell membrane labeling.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2015
    Article
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert A MarrDepartment of Neuroscience, Center for Stem Cell & Regenerative Medicine, Rosalind Franklin University of Medicine & Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
Rosanne M Thomas
Daniel A Peterson

Funding

Stem Cells for Brain RepairR01AG020047 · NIA · ROSALIND FRANKLIN UNIV OF MEDICINE &SCI · PI PETERSON, DANIEL ALAN · 2001 to 2013
$2.5M
Neurogenesis in the Aging BrainR01AG022555 · NIA · ROSALIND FRANKLIN UNIV OF MEDICINE &SCI · PI PETERSON, DANIEL ALAN · 2003 to 2007
$1.8M
NIA NIH HHS R01 AG020047NIA NIH HHS R01 AG022555
6 · The paper itself

Abstract

Neurogenesis is the process by which new neural cells are generated from a small population of multipotent stem cells in the adult CNS. This natural generation of new cells is limited in its regenerative capabilities and also declines with age. The use of stem cells in the treatment of neurodegenerative disease may hold great potential; however, the age-related incidence of many CNS diseases coincides with reduced neurogenesis. This review concisely summarizes current knowledge related to adult neurogenesis and its alteration with aging and examines the feasibility of using stem cell and gene therapies to combat diseases of the CNS with advancing age.

Identifiers

PMID20806052
PMCPMC2929019

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.