ArticlePloS one2010
Selenoproteins are essential for proper keratinocyte function and skin development.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 105 citations in OpenAlex.
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- Beyond the Follicle: A Narrative Review on How Systemic Diseases and Drugs Affect Alopecia.Pharmaceutical medicine · 2026Review
- Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.Current medicinal chemistry · 2025Review
- Cell death as an architect of adult skin stem cell niches.Cell death and differentiation · 2024Review
- Effects of Dietary Selenium Yeast Supplementation in Pregnant Cashmere Goats on the Development of Offspring Hair Follicles.Animals : an open access journal from MDPI · 2024Article
- Selenium Compounds Affect Differently the Cytoplasmic Thiol/Disulfide State in Dermic Fibroblasts and Improve Cell Migration by Interacting with the Extracellular Matrix.Antioxidants (Basel, Switzerland) · 2024Article
- Utilizing Robust Design to Optimize Composite Bioadhesive for Promoting Dermal Wound Repair.Polymers · 2023Article
- In Vitro Evaluation of Bioavailability of Se from Daily Food Rations and Dietary Supplements.Nutrients · 2023Article
- Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss.Journal of clinical medicine · 2023Review
- An overview of the genetic aspects of hair loss and its connection with nutrition.Journal of preventive medicine and hygiene · 2022Review
- Ferroptosis: Mechanism and connections with cutaneous diseases.Frontiers in cell and developmental biology · 2022Review
- Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly.International journal of molecular sciences · 2021Review
- Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency.International journal of molecular sciences · 2021Review
- Trace elements in subantarctic false killer whale (Pseudorca crassidens) tissues, including the skin as an offshore bioindicator.Environmental science and pollution research international · 2021Article
- Diet and Skin Aging-From the Perspective of Food Nutrition.Nutrients · 2020Review
- Selenium and mercury in the hair of raccoons (Procyon lotor) and European wildcats (Felis s. silvestris) from Germany and Luxembourg.Ecotoxicology (London, England) · 2020Article
- Pomegranate (Journal of functional foods · 2019Article
- Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome.International journal of molecular sciences · 2018Review
- An antibacterial platform based on capacitive carbon-doped TiONature communications · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Dietary selenium is known to protect skin against UV-induced damage and cancer and its topical application improves skin surface parameters in humans, while selenium deficiency compromises protective antioxidant enzymes in skin. Furthermore, skin and hair abnormalities in humans and rodents may be caused by selenium deficiency, which are overcome by dietary selenium supplementation. Most important biological functions of selenium are attributed to selenoproteins, proteins containing selenium in the form of the amino acid, selenocysteine (Sec). Sec insertion into proteins depends on Sec tRNA; thus, knocking out the Sec tRNA gene (Trsp) ablates selenoprotein expression. We generated mice with targeted removal of selenoproteins in keratin 14 (K14) expressing cells and their differentiated descendents. The knockout progeny had a runt phenotype, developed skin abnormalities and experienced premature death. Lack of selenoproteins in epidermal cells led to the development of hyperplastic epidermis and aberrant hair follicle morphogenesis, accompanied by progressive alopecia after birth. Further analyses revealed that selenoproteins are essential antioxidants in skin and unveiled their role in keratinocyte growth and viability. This study links severe selenoprotein deficiency to abnormalities in skin and hair and provides genetic evidence for the role of these proteins in keratinocyte function and cutaneous development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.