ArticlePloS one2010
Inferring geographic coordinates of origin for Europeans using small panels of ancestry informative markers.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Spatial localization of recent ancestors for admixed individuals.G3 (Bethesda, Md.) · 2014Article
- Using ancestry-informative markers to identify fine structure across 15 populations of European origin.European journal of human genetics : EJHG · 2014Article
- Racial and ethnic health disparities in reproductive medicine: an evidence-based overview.Seminars in reproductive medicine · 2013Review
- Inference of human continental origin and admixture proportions using a highly discriminative ancestry informative 41-SNP panel.Investigative genetics · 2013Article
- Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity.European journal of human genetics : EJHG · 2013Article
- Genetic ancestry inference using support vector machines, and the active emergence of a unique American population.European journal of human genetics : EJHG · 2013Article
- Anisotropic isolation by distance: the main orientations of human genetic differentiation.Molecular biology and evolution · 2013Article
- Heritability of pulmonary function estimated from pedigree and whole-genome markers.Frontiers in genetics · 2013Article
- A comprehensive genetic approach for improving prediction of skin cancer risk in humans.Genetics · 2012Article
- Genetic clustering of European cancer patients indicates that opioid-mediated pain relief is independent of ancestry.The pharmacogenomics journal · 2012Article
- Integrative analysis of single nucleotide polymorphisms and gene expression efficiently distinguishes samples from closely related ethnic populations.BMC genomics · 2012Article
- Sparse principal component analysis for identifying ancestry-informative markers in genome-wide association studies.Genetic epidemiology · 2012Article
- European American stratification in ovarian cancer case control data: the utility of genome-wide data for inferring ancestry.PloS one · 2012Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Recent large-scale studies of European populations have demonstrated the existence of population genetic structure within Europe and the potential to accurately infer individual ancestry when information from hundreds of thousands of genetic markers is used. In fact, when genomewide genetic variation of European populations is projected down to a two-dimensional Principal Components Analysis plot, a surprising correlation with actual geographic coordinates of self-reported ancestry has been reported. This substructure can hamper the search of susceptibility genes for common complex disorders leading to spurious correlations. The identification of genetic markers that can correct for population stratification becomes therefore of paramount importance. Analyzing 1,200 individuals from 11 populations genotyped for more than 500,000 SNPs (Population Reference Sample), we present a systematic exploration of the extent to which geographic coordinates of origin within Europe can be predicted, with small panels of SNPs. Markers are selected to correlate with the top principal components of the dataset, as we have previously demonstrated. Performing thorough cross-validation experiments we show that it is indeed possible to predict individual ancestry within Europe down to a few hundred kilometers from actual individual origin, using information from carefully selected panels of 500 or 1,000 SNPs. Furthermore, we show that these panels can be used to correctly assign the HapMap Phase 3 European populations to their geographic origin. The SNPs that we propose can prove extremely useful in a variety of different settings, such as stratification correction or genetic ancestry testing, and the study of the history of European populations.
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