ArticleProceedings of the National Academy of Sciences of the United States of America2010
Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchyme.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- New insights into Müllerian duct differentiation provided by single cell transcriptomics in the chicken embryo.PLoS genetics · 2026Article
- Wt1 Is Required for the Regression of Müllerian Ducts in Male Mice by Inducing Wif1 and Osx Expression.Cell proliferation · 2026Article
- Improving data interpretability with new differential sample variance gene set tests.BMC bioinformatics · 2025Article
- Development and characterization of human fetal female reproductive tract organoids to understand Müllerian duct anomalies.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- WNT4 Balances Development vs Disease in Gynecologic Tissues and Women's Health.Endocrinology · 2021Review
- A tale of two tracts: history, current advances, and future directions of research on sexual differentiation of reproductive tracts†.Biology of reproduction · 2019Review
- Article
- Developmental Contribution of Wnt-signal-responsive Cells to Mouse Reproductive Tract Formation.Acta histochemica et cytochemica · 2017Article
- Overactivation of hedgehog signaling in the developing Müllerian duct interferes with duct regression in males and causes subfertility.Reproduction (Cambridge, England) · 2017Article
- Germ cell-specific sustained activation of Wnt signalling perturbs spermatogenesis in aged mice, possibly through non-coding RNAs.Oncotarget · 2016Article
- Ovarian hormones through Wnt signalling regulate the growth of human and mouse ovarian cancer initiating lesions.Oncotarget · 2016Article
- Germ cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development.Scientific reports · 2016Article
- Partial Müllerian Duct Retention in Smad4 Conditional Mutant Male Mice.International journal of biological sciences · 2016Article
- Induction of WNT inhibitory factor 1 expression by Müllerian inhibiting substance/antiMullerian hormone in the Müllerian duct mesenchyme is linked to Müllerian duct regression.Developmental biology · 2014Article
- Molecular genetics of Müllerian duct formation, regression and differentiation.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2014Review
- Anti-müllerian hormone: a valuable addition to the toolbox of the pediatric endocrinologist.International journal of endocrinology · 2013Review
- The Müllerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained β-catenin signaling.Carcinogenesis · 2012Article
- Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.Human molecular genetics · 2012Article
- Article
- Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Müllerian-inhibiting substance (MIS), which is produced by fetal Sertoli cells shortly after commitment of the bipotential gonads to testicular differentiation, causes Müllerian duct (MD) regression. In the fetal female gonads, MIS is not expressed and the MDs will differentiate into the internal female reproductive tract. We have investigated whether dysregulated β-catenin activity affects MD regression by expressing a constitutively activated nuclear form of β-catenin in the MD mesenchyme. We show that constitutively activated (CA) β-catenin causes focal retention of MD tissue in the epididymides and vasa deferentia. In adult mutant mice, the retained MD tissues express α-smooth muscle actin and desmin, which are markers for uterine differentiation. MD retention inhibited the folding complexity of the developing epididymides and usually led to obstructive azoospermia by spermatoceles. The MDs of urogenital ridges from mutant female embryos showed less regression with added MIS in organ culture compared with control MDs when analyzed by whole mount in situ hybridization for Wnt7a as a marker for the MD epithelium. CA β-catenin did not appear to affect expression of either MIS in the embryonic testes or its type II receptor (AMHR2) in the MD mesenchyme nor did it inhibit pSmad1/5/8 nuclear accumulation, suggesting that dysregulated β-catenin must inhibit MD regression independently of MIS signaling. These studies suggest that dysregulated Wnt/β-catenin signaling in the MD mesenchyme might also be a contributing factor in persistent Müllerian duct syndrome, a form of male pseudohermaphroditism, and development of spermatoceles.
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