ArticleProceedings of the National Academy of Sciences of the United States of America2010
Social interaction modulates autonomic, inflammatory, and depressive-like responses to cardiac arrest and cardiopulmonary resuscitation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Association between physical, cognitive, and social activities with the incident of sarcopenia among community-dwelling older adults: a 4-year longitudinal study.European geriatric medicine · 2024Article
- Social enrichment attenuates chemotherapy induced pro-inflammatory cytokine production and affective behavior via oxytocin signaling.Brain, behavior, and immunity · 2020Article
- Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury.International journal of molecular sciences · 2020Article
- Dim light at night impairs recovery from global cerebral ischemia.Experimental neurology · 2019Article
- Late aging alters behavioral sensitivity to ethanol in a sex-specific manner in Fischer 344 rats.Pharmacology, biochemistry, and behavior · 2018Article
- Social influences on microglial reactivity and neuronal damage after cardiac arrest/cardiopulmonary resuscitation.Physiology & behavior · 2018Article
- Stress and aging act through common mechanisms to elicit neuroinflammatory priming.Brain, behavior, and immunity · 2018Review
- Social interaction modulates the neuroinflammatory response to global cerebral ischemia in male mice.Brain research · 2017Article
- Chronic Social Stress Time-Dependently Affects Neuropathic Pain-Related Cold Allodynia and Leads to Altered Expression of Spinal Biochemical Mediators.Frontiers in behavioral neuroscience · 2017Article
- Microglial Acid Sensing Regulates Carbon Dioxide-Evoked Fear.Biological psychiatry · 2016Article
- Improved Survival and Neurological Outcomes after Cardiopulmonary Resuscitation in Toll-like Receptor 4-mutant Mice.Chinese medical journal · 2015Article
- Social conditioned place preference in the captive ground squirrel (Ictidomys tridecemlineatus): Social reward as a natural phenotype.Journal of comparative psychology (Washington, D.C. : 1983) · 2015Article
- One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition.Acta neuropathologica · 2015Review
- Toward a neurology of loneliness.Psychological bulletin · 2014Review
- Of mice and men: modelling post-stroke depression experimentally.British journal of pharmacology · 2014Review
- Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin.Anesthesiology · 2013Article
- Effects of social isolation on glucocorticoid regulation in social mammals.Hormones and behavior · 2012Review
- Chronic social isolation in the prairie vole induces endothelial dysfunction: implications for depression and cardiovascular disease.Physiology & behavior · 2012Article
- Socially isolated mice exhibit a blunted homeostatic sleep response to acute sleep deprivation compared to socially paired mice.Brain research · 2012Article
- Peripheral oxytocin administration buffers autonomic but not behavioral responses to environmental stressors in isolated prairie voles.Stress (Amsterdam, Netherlands) · 2012Article
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Authors and funding
6 authors.
Funding
Abstract
Psychological factors, including depression and social isolation, are important determinants of cardiovascular health. The current study uses a well-validated mouse model of cardiac arrest/cardiopulmonary resuscitation (CA/CPR) to examine the effect of social environment on several pathophysiological and behavioral responses to cerebral ischemia. Male experimental mice were either housed in pairs with an ovariectomized female or socially isolated for the duration of the experiment. Cardiac arrest increased the mRNA expression of the proinflammatory cytokines TNF-α, IL-1β, and IL-6, as well as the microglia marker MAC-1; expression of each of these factors, except IL-6, was further increased among socially isolated mice. Furthermore, socially isolated animals exposed to the CA/CPR procedure displayed significantly higher levels of neuronal cell death and microglia staining within the hippocampus at 7 d following surgery. Social isolation also exacerbated CA/CPR-induced depressive-like behavior and cardiac autonomic dysregulation. In the absence of ischemic damage, social environment had no significant effect on the expression of neuronal cell death, autonomic cardiac control, or behavior. Together, these data suggest that social factors influence the pathophysiological trajectory following cardiac arrest.
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