ArticleProceedings of the National Academy of Sciences of the United States of America2010
Elr-type proteins protect Xenopus Dead end mRNA from miR-18-mediated clearance in the soma.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- RNA localization during early development of the axolotl.Frontiers in cell and developmental biology · 2023Article
- The Role of DND1 in Cancers.Cancers · 2021Review
- Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse.Nucleic acids research · 2020Article
- Novel functions of the ubiquitin-independent proteasome system in regulatingDevelopment (Cambridge, England) · 2019Article
- Combined functions of two RRMs in Dead-end1 mimic helicase activity to promote nanos1 translation in the germline.Molecular reproduction and development · 2018Article
- Primordial Germ Cell Transplantation for CRISPR/Cas9-based Leapfrogging in Xenopus.Journal of visualized experiments : JoVE · 2018Article
- Maternal Dead-end 1 promotes translation ofDevelopment (Cambridge, England) · 2017Article
- Maternal messages to live by: a personal historical perspective.Genesis (New York, N.Y. : 2000) · 2017Review
- Leapfrogging: primordial germ cell transplantation permits recovery of CRISPR/Cas9-induced mutations in essential genes.Development (Cambridge, England) · 2016Article
- Global analysis of asymmetric RNA enrichment in oocytes reveals low conservation between closely related Xenopus species.Molecular biology of the cell · 2015Article
- The Xenopus Maternal-to-Zygotic Transition from the Perspective of the Germline.Current topics in developmental biology · 2015Review
- mRNA localization in the Drosophila germline.RNA biology · 2014Review
- Migratory and adhesive properties of Xenopus laevis primordial germ cells in vitro.Biology open · 2013Article
- Maternal Dead-End1 is required for vegetal cortical microtubule assembly during Xenopus axis specification.Development (Cambridge, England) · 2013Article
- Principles and roles of mRNA localization in animal development.Development (Cambridge, England) · 2012Review
- Article
- Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- HuB (elavl2) mRNA is restricted to the germ cells by post-transcriptional mechanisms including stabilisation of the message by DAZL.PloS one · 2011Article
- RNA Localization in the Vertebrate Oocyte: Establishment of Oocyte Polarity and Localized mRNA Assemblages.Results and problems in cell differentiationReview
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Segregation of the future germ line defines a crucial cell fate decision during animal development. In Xenopus, germ cells are specified by inheritance of vegetally localized maternal determinants, including a group of specific mRNAs. Here, we show that the vegetal localization elements (LE) of Xenopus Dead end (XDE) and of several other germ-line-specific, vegetally localized transcripts mediate germ cell-specific stabilization and somatic clearance of microinjected reporter mRNA in Xenopus embryos. The part of XDE-LE critical for somatic RNA clearance exhibits homology to zebrafish nanos1 and appears to be targeted by Xenopus miR-18 for somatic mRNA clearance. Xenopus Elr-type proteins of the vegetal localization complex can alleviate somatic RNA clearance of microinjected XDE-LE and endogenous XDE mRNA. ElrB1 synergizes with Xenopus Dead end protein in the stabilization of XDE-LE mRNA. Taken together, our findings unveil a functional link of vegetal mRNA localization and the protection of germ-line mRNAs from somatic clearance.
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