ArticlePlant physiology2010
WAVY LEAF1, an ortholog of Arabidopsis HEN1, regulates shoot development by maintaining MicroRNA and trans-acting small interfering RNA accumulation in rice.
Article in Plant physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 86 citations in OpenAlex.
- To awn or not to awn: Revisiting the evolution of awnedness during rice domestication and improvement.Plant communications · 2026Review
- DNA Methylation in Rice: Mechanisms, Regulatory Roles, and Beyond.International journal of molecular sciences · 2025Review
- OsLC1, a transaldolase, regulates cell patterning and leaf morphology through modulation of secondary metabolism.Plant biotechnology journal · 2025Article
- DNA methylation dynamics play crucial roles in shaping the distinct transcriptomic profiles for different root-type initiation in rice.Genome biology · 2025Article
- Biochemical and transcriptomic profiling analysis of drought tolerant related genes in ML 82-2 and ML 125-2 rice mutant lines.Biotechnologia · 2025Article
- Article
- Melon shoot organization 1, encoding an AGRONAUTE7 protein, plays a crucial role in plant development.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- The rice EP3 and OsFBK1 E3 ligases alter plant architecture and flower development, and affect transcript accumulation of microRNA pathway genes and their targets.Plant biotechnology journal · 2022Article
- An atypical class of non-coding small RNAs is produced in rice leaves upon bacterial infection.Scientific reports · 2021Article
- Loss of Function ofLife (Basel, Switzerland) · 2021Article
- Characterizing the Role of the miR156-SPL Network in Plant Development and Stress Response.Plants (Basel, Switzerland) · 2020Review
- Genome-wide DNA hypomethylation shapes nematode pattern-triggered immunity in plants.The New phytologist · 2020Article
- Overexpression of OsAGO1b Induces Adaxially Rolled Leaves by Affecting Leaf Abaxial Sclerenchymatous Cell Development in Rice.Rice (New York, N.Y.) · 2019Article
- Analysing the rice young panicle transcriptome reveals the gene regulatory network controlled by TRIANGULAR HULL1.Rice (New York, N.Y.) · 2019Article
- RNA uridylation and decay in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- A rust fungal effector binds plant DNA and modulates transcription.Scientific reports · 2018Article
- Plant small RNAs: advancement in the understanding of biogenesis and role in plant development.Planta · 2018Review
- CRISPR/Cas9 and TALENs generate heritable mutations for genes involved in small RNA processing of Glycine max and Medicago truncatula.Plant biotechnology journal · 2018Article
- The gymnastics of epigenomics in rice.Plant cell reports · 2018Review
- funRiceGenes dataset for comprehensive understanding and application of rice functional genes.GigaScience · 2018Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In rice (Oryza sativa), trans-acting small interfering RNA (ta-siRNA) is essential for shoot development, including shoot apical meristem (SAM) formation and leaf morphogenesis. The rice wavy leaf1 (waf1) mutant has been identified as an embryonic mutant resembling shoot organization1 (sho1) and sho2, homologs of a loss-of-function mutant of DICER-LIKE4 and a hypomorphic mutant of ARGONAUTE7, respectively, which both act in the ta-siRNA production pathway. About half of the waf1 mutants showed seedling lethality due to defects in SAM maintenance, but the rest survived to the reproductive phase and exhibited pleiotropic phenotypes in leaf morphology and floral development. Map-based cloning of WAF1 revealed that it encodes an RNA methyltransferase, a homolog of Arabidopsis (Arabidopsis thaliana) HUA ENHANCER1. The reduced accumulation of small RNAs in waf1 indicated that the stability of the small RNA was decreased. Despite the greatly reduced level of microRNAs and ta-siRNA, microarray and reverse transcription-polymerase chain reaction experiments revealed that the expression levels of their target genes were not always enhanced. A double mutant between sho and waf1 showed an enhanced SAM defect, suggesting that the amount and/or quality of ta-siRNA is crucial for SAM maintenance. Our results indicate that stabilization of small RNAs by WAF1 is indispensable for rice development, especially for SAM maintenance and leaf morphogenesis governed by the ta-siRNA pathway. In addition, the inconsistent relationship between the amount of small RNAs and the level of the target mRNA in waf1 suggest that there is a complex regulatory mechanism that modifies the effects of microRNA/ta-siRNA on the expression of the target gene.
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