ArticleDiabetes care2010
Diabetic neuropathy: a cross-sectional study of the relationships among tests of neurophysiology.
Article in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05099367 (Prostacyclin), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prostacyclin (PGI2) Pathway to Enhance Wound Healing in Diabetic Foot Ulcers
Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Laser Doppler imaging in the detection of peripheral neuropathy.Autonomic neuroscience : basic & clinical · 2013Trial
- Thermal threshold: research study on small fiber dysfunction in distal diabetic polyneuropathy.Journal of diabetes science and technology · 2012Trial
- Low serum CTRP3 is related to more severe distal symmetric polyneuropathy in type 2 diabetes patients.Hormones (Athens, Greece) · 2025Article
- Magnetization transfer ratio of the sciatic nerve differs between patients in type 1 and type 2 diabetes.European radiology experimental · 2024Article
- Potential predictive effect of mechanical properties of the plantar skin and superficial soft tissue, and vibration perception on plantar loading during gait in individuals with diabetes.BMC musculoskeletal disorders · 2023Article
- Sciatic nerve fractional anisotropy and neurofilament light chain protein are related to sensorimotor deficit of the upper and lower limbs in patients with type 2 diabetes.Frontiers in endocrinology · 2023Article
- Corneal confocal microscopy in patients with distal symmetric polyneuropathy compared to controls.Arquivos de neuro-psiquiatria · 2022Article
- Sciatic nerve microvascular permeability in type 2 diabetes decreased in patients with neuropathy.Annals of clinical and translational neurology · 2022Article
- Troponin T Is Negatively Associated With 3 Tesla Magnetic Resonance Peripheral Nerve Perfusion in Type 2 Diabetes.Frontiers in endocrinology · 2022Article
- Autonomic and Somatic Nerve Functions in Type 2 Diabetes Mellitus Patients: Electrophysiological Aspects.Diagnostics (Basel, Switzerland) · 2021Article
- The Mechanoreceptor's Role in Plantar Skin Changes in Individuals with Diabetes Mellitus.Journal of clinical medicine · 2021Article
- Clinical study of diabetic peripheral neuropathy screening by retinal vascular geometric parameters.Scientific reports · 2021Article
- Fractional Anisotropy and Troponin T Parallel Structural Nerve Damage at the Upper Extremities in a Group of Patients With Prediabetes and Type 2 Diabetes - A Study Using 3T Magnetic Resonance Neurography.Frontiers in neuroscience · 2021Article
- Early identification of peripheral neuropathy based on sudomotor dysfunction in Mexican patients with type 2 diabetes.BMC neurology · 2019Article
- Axon reflex-mediated vasodilation is reduced in proportion to disease severity in TTR-FAP.Neurology. Genetics · 2018Article
- Laser Doppler Assessment of Vasomotor Axon Reflex Responsiveness to Evaluate Neurovascular Function.Frontiers in neurology · 2017Review
- Endothelial Dysfunction as a Link Between Cardiovascular Risk Factors and Peripheral Neuropathy in Diabetes.The Journal of clinical endocrinology and metabolism · 2016Article
- Cardiovagal and somatic sensory nerve functions in healthy subjects.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2015Article
- Detecting subtle fingertip sensory and motor dysfunction in adults with type II diabetes.Experimental brain research · 2014Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine the relationships among large, small, and autonomic fiber neurophysiological measures in a cross-sectional study of patients with diabetes. RESEARCH DESIGN AND
methodsWe assessed 130 individuals: 25 healthy subjects and 105 subjects with diabetes. Subjects were classified by the presence or absence of neuropathy by physical examination. All subjects underwent autonomic testing, nerve conduction studies, quantitative sensory testing, and nerve-axon reflex vasodilation in addition to quantifiable neurological examination and symptom scores. Correlation and cluster analysis were used to determine relationships between and among different neurophysiological testing parameters.
resultsResults of neurophysiological tests were abnormal in patients with clinical evidence of diabetic neuropathy compared with results in healthy control subjects and in those without neuropathy (P < 0.01, all tests). The correlations among individual tests varied widely, both within (r range <0.5->0.9, NS to <0.001) and between test groups (r range <0.2->0.5, NS to <0.01). A two-step hierarchical cluster analysis revealed that neurophysiological tests do not aggregate by typical "small," "large," or "autonomic" nerve fiber subtypes.
conclusionsThe modest correlation coefficients seen between the different testing modalities suggest that these techniques measure different neurophysiological parameters and are therefore not interchangeable. However, the data suggest that only a small number of neurophysiological tests are actually required to clinically differentiate individuals with neuropathy from those without. The natural clustering of both patients and healthy control subjects suggests that variations in the population will need to be considered in future studies of diabetic neuropathy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.