Trial reportDiabetes care2010
Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study.
Trial report in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- The risk of new-onset diabetes in antidepressant users - A systematic review and meta-analysis.PloS one · 2017Pooled it
- Antidepressant medication as a risk factor for type 2 diabetes and impaired glucose regulation: systematic review.Diabetes care · 2013Pooled it
- Use of antidepressant medication and risk of type 2 diabetes: results from three cohorts of US adults.Diabetologia · 2012Pooled it
- Long-term effects and effect heterogeneity of lifestyle and metformin interventions on type 2 diabetes incidence over 21 years in the US Diabetes Prevention Program randomised clinical trial.The lancet. Diabetes & endocrinology · 2025Trial
- Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study.BMC psychiatry · 2018Trial
- Effect of collaborative depression treatment on risk for diabetes: A 9-year follow-up of the IMPACT randomized controlled trial.PloS one · 2018Trial
- Depressive symptoms, antidepressant medication use, and new onset of diabetes in participants of the diabetes prevention program and the diabetes prevention program outcomes study.Psychosomatic medicine · 2015Trial
- Weight and metabolic effects of dietary weight loss and exercise interventions in postmenopausal antidepressant medication users and non-users: a randomized controlled trial.Preventive medicine · 2013Trial
- Depression as a predictor of weight regain among successful weight losers in the diabetes prevention program.Diabetes care · 2013Trial
- Results of a proof-of-concept, dose-finding, double-blind, placebo-controlled study of RX-10100 (Serdaxin®) in subjects with major depressive disorder.Psychopharmacology · 2012Trial
- Depressive Symptoms, Antidepressant Medication Use, and Inflammatory Markers in the Diabetes Prevention Program.Psychosomatic medicineTrial
- Diabetes Mellitus Inequality in South Korean Adults by Region: The Influence of Obesity and Depression.Iranian journal of public health · 2024Article
- Association between Depression, Antidepression Medications, and the Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study in Taiwan.BioMed research international · 2021Article
- New research directions on disparities in obesity and type 2 diabetes.Annals of the New York Academy of Sciences · 2020Article
- The Impact of Antidepressant Therapy on Glycemic Control in Canadian Primary Care Patients With Diabetes Mellitus.Frontiers in nutrition · 2018Article
- Association of Antidepressant Medications With Incident Type 2 Diabetes Among Medicaid-Insured Youths.JAMA pediatrics · 2017Article
- Therapeutic Use of Metformin in Prediabetes and Diabetes Prevention.Drugs · 2015 · on this mapReview
- Prevention of Diabetes Through the Lifestyle Intervention: Lessons Learned from the Diabetes Prevention Program and Outcomes Study and its Translation to Practice.Current nutrition reports · 2014Article
- Depressive symptoms, antidepressant use, and the incidence of diabetes in the Black Women's Health Study.Diabetes care · 2014Article
- NIDDK international conference report on diabetes and depression: current understanding and future directions.Diabetes care · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS). RESEARCH DESIGN AND
methodsDPP/DPPOS participants were assessed for diabetes every 6 months and for antidepressant use every 3 months in DPP and every 6 months in DPPOS for a median 10.0-year follow-up.
resultsControlled for factors associated with diabetes risk, continuous antidepressant use compared with no use was associated with diabetes risk in the placebo (adjusted hazard ratio 2.34 [95% CI 1.32-4.15]) and lifestyle (2.48 [1.45-4.22]) arms, but not in the metformin arm (0.55 [0.25-1.19]).
conclusionsContinuous antidepressant use was significantly associated with diabetes risk in the placebo and lifestyle arms. Measured confounders and mediators did not account for this association, which could represent a drug effect or reflect differences not assessed in this study between antidepressant users and nonusers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.