ArticleThorax2010
Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes.
Article in Thorax, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 107 citations in OpenAlex.
- Reproducibility of airway luminal size in asthma measured by HRCT.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Longitudinal changes in airway remodeling and air trapping in severe asthma.Academic radiology · 2014Trial
- Childhood asthma clusters and response to therapy in clinical trials.The Journal of allergy and clinical immunology · 2014Trial
- Vascular remodeling in asthma: from mechanisms to precision medicine.Current opinion in allergy and clinical immunology · 2026Review
- Quantitative Computed Tomographic Clusters in C-BIOPRED Asthma Cohort: Association with Sputum Proteomics.MedComm · 2025Article
- Overnight deep inspiration patterns in obstructive sleep apnea patients with and without asthma.Physiological reports · 2025Article
- Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics.The European respiratory journal · 2024Article
- The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma.International journal of molecular sciences · 2024Review
- Do Patients with Bronchiectasis Have an Increased Risk of Developing Lung Cancer? A Systematic Review.Life (Basel, Switzerland) · 2023Review
- Review
- Phenotypic clusters on computed tomography reflects asthma heterogeneity and severity.The World Allergy Organization journal · 2022Article
- Novel imaging phenotypes of naïve asthma patients with distinctive clinical characteristics and T2 inflammation traits.Therapeutic advances in chronic disease · 2022Article
- De-labelling severe asthma diagnosis: the challenge of DIPNECH.ERJ open research · 2022Article
- A Systematic Review of Asthma Phenotypes Derived by Data-Driven Methods.Diagnostics (Basel, Switzerland) · 2021Review
- Is bronchiectasis really a disease?European respiratory review : an official journal of the European Respiratory Society · 2020Article
- Quantitative analysis of computed tomography of the lungs in patients with lymphangioleiomyomatosis treated with sirolimus.Heliyon · 2020Article
- Dismantling the pathophysiology of asthma using imaging.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Uncontrolled asthma phenotypes defined from parameters using quantitative CT analysis.European radiology · 2019Article
- Physiological and morphological differences of airways between COPD and asthma-COPD overlap.Scientific reports · 2019Observational
- Lumen area change (Delta Lumen) between inspiratory and expiratory multidetector computed tomography as a measure of severe outcomes in asthmatic patients.The Journal of allergy and clinical immunology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSevere asthma is a heterogeneous condition. Airway remodelling is a feature of severe asthma and can be determined by the assessment of high-resolution computed tomography (HRCT) scans. The aim of this study was to assess whether airway remodelling is restricted to specific subphenotypes of severe asthma.
methodsA retrospective analysis was performed of HRCT scans from subjects who had attended a single-centre severe asthma clinic between 2003 and 2008. The right upper lobe apical segmental bronchus (RB1) dimensions were measured and the clinical and sputum inflammatory characteristics associated with RB1 geometry were assessed by univariate and multivariate regression analyses. Longitudinal sputum data were available and were described as area under the time curve (AUC). Comparisons were made in RB1 geometry across subjects in four subphenotypes determined by cluster analysis, smokers and non-smokers, and subjects with and without persistent airflow obstruction.
resultsNinety-nine subjects with severe asthma and 16 healthy controls were recruited. In the subjects with severe asthma the RB1 percentage wall area (%WA) was increased (p=0.009) and lumen area (LA)/body surface area (BSA) was decreased (p=0.008) compared with controls but was not different across the four subphenotypes. Airway geometry was not different between smokers and non-smokers and RB1 %WA was increased in those with persistent airflow obstruction. RB1 %WA in severe asthma was best associated with airflow limitation and persistent neutrophilic airway inflammation (model R(2)=0.27, p=0.001).
conclusionsAirway remodelling of proximal airways occurs in severe asthma and is associated with impaired lung function and neutrophilic airway inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.