Evidence map›Paper›PMID 20805096›Full record

ReviewCardiovascular research2010

What can we learn about cardioprotection from the cardiac mitochondrial proteome?

Marjan Gucek, Elizabeth Murphy

Open access · bronzeAbstract readReview
In one paragraph

Review in Cardiovascular research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Proteomics of the heart.Physiological reviews · 2024
    Review
  2. Characterization of the sex-dependent myocardial S-nitrosothiol proteome.American journal of physiology. Heart and circulatory physiology · 2016
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. S-nitrosylation: a radical way to protect the heart.Journal of molecular and cellular cardiology · 2012
    Review
  13. Review
  14. Proteomics approaches to fibrotic disorders.Fibrogenesis & tissue repair · 2012
    Article
  15. Article
  16. Article
  17. Proteomic remodeling of mitochondria in heart failure.Congestive heart failure (Greenwich, Conn.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Marjan GucekNHLBI Proteomics Core, NHLBI, NIH, 10 Center Drive, Bethesda, MD 20892, USA.
Elizabeth Murphy
National Heart Lung and Blood Institute · USNational Institutes of Health · US

Funding

Proteomics CoreZICHL005903 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI GUCEK, MARJAN · 2009 to 2022
$23.3M
Mechanisms of cardiac ischemia-reperfusion injury and cardioprotectionZIAHL002066 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2009 to 2025
$20.4M
Role of S-nitrosylation in regulating cardiac function and diseaseZIAHL006059 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2010 to 2025
$7.2M
6 · The paper itself

Abstract

This review will summarize proteomic methods that are useful in studying the role of mitochondria in cardioprotection. The strengths and weaknesses of some of the different approaches are discussed. We focus on the cardiac mitochondrial proteome with emphasis on changes associated with cell death and protection, and we summarize how proteomic data have contributed to addressing the role of mitochondria in cardioprotection.

Indexed as

Ischemic Preconditioning, MyocardialAnimalsCardiotonic AgentsCell DeathHumansMitochondria, HeartMitochondrial ProteinsMyocardial Reperfusion InjuryMyocardiumProtein Processing, Post-TranslationalProteomicsCardiotonic AgentsMitochondrial Proteins

Identifiers

PMID20805096
PMCPMC2952536
OpenAlexW2096084280

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.