ArticleNeuroImage2011
Imaging separation of neuronal from vascular effects of cocaine on rat cortical brain in vivo.
Article in NeuroImage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- Cocaine-Induced Ocular Toxicity.Diseases (Basel, Switzerland) · 2026Review
- Cocaine induced astrocytic activation was associated with its vasoconstricting effects independent of its neuronal effects in the prefrontal cortex.Scientific reports · 2026Article
- Inhibition of iNOS reduced cerebral vasoconstriction from chronic cocaine and enhanced angiogenesis in the prefrontal cortex.Brain research bulletin · 2025Article
- Evidence of cortical vascular impairments in early stage of Alzheimer's transgenic mice: Optical imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Review of cocaine-induced brain vascular and cellular function changes measuredNeurophotonics · 2025Review
- Astrocytes modulate cerebral blood flow and neuronal response to cocaine in prefrontal cortex.Molecular psychiatry · 2024Article
- Neurovascular effects of cocaine: relevance to addiction.Frontiers in pharmacology · 2024Review
- Impairment of cerebral vascular reactivity and resting blood flow in early-staged transgenic AD mice:Research square · 2023Article
- Cocaine's cerebrovascular vasoconstriction is associated with astrocytic CaCommunications biology · 2022Article
- Cocaine's effects on the reactivity of the medial prefrontal cortex to ventral tegmental area stimulation: optical imaging study in mice.Addiction (Abingdon, England) · 2022Article
- Memantine Attenuates Cocaine and neuroHIV Neurotoxicity in the Medial Prefrontal Cortex.Frontiers in pharmacology · 2022Article
- Advanced high resolution three-dimensional imaging to visualize the cerebral neurovascular network in stroke.International journal of biological sciences · 2022Review
- CaTranslational psychiatry · 2021Article
- Optical imaging of stimulation-evoked cortical activity using GCaMP6f and jRGECO1a.Quantitative imaging in medicine and surgery · 2021Article
- Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI.Scientific reports · 2020Article
- Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents.Molecular psychiatry · 2020Article
- Interactions between stimuli-evoked cortical activity and spontaneous low frequency oscillations measured with neuronal calcium.NeuroImage · 2020Article
- Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats.Addiction biology · 2019Article
- Vascular disease in cocaine addiction.Atherosclerosis · 2017Review
- Cocaine attenuates blood flow but not neuronal responses to stimulation while preserving neurovascular coupling for resting brain activity.Molecular psychiatry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
MRI techniques to study brain function assume coupling between neuronal activity, metabolism and flow. However, recent evidence of physiological uncoupling between neuronal and cerebrovascular events highlights the need for methods to simultaneously measure these three properties. We report a multimodality optical approach that integrates dual-wavelength laser speckle imaging (measures changes in blood flow, blood volume and hemoglobin oxygenation), digital-frequency-ramping optical coherence tomography (images quantitative 3D vascular network) and Rhod(2) fluorescence (images intracellular calcium for measure of neuronal activity) at high spatiotemporal resolutions (30 μm, 10 Hz) and over a large field of view (3×5 mm(2)). We apply it to assess cocaine's effects in rat cortical brain and show an immediate decrease (3.5±0.9 min, phase 1) in the oxygen content of hemoglobin and the cerebral blood flow followed by an overshoot (7.1±0.2 min, phase 2) lasting over 20 min whereas Ca(2+) increased immediately (peaked at t=4.1±0.4 min) and remained elevated. This enabled us to identify a delay (2.9±0.5 min) between peak neuronal and vascular responses in phase 2. The ability of this multimodality optical approach for simultaneous imaging at high spatiotemporal resolutions permits us to distinguish the vascular versus cellular changes of the brain, thus complimenting other neuroimaging modalities for brain functional studies (e. g., PET, fMRI).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.