ArticleFEBS letters2010
Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription.
Article in FEBS letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- CEBPB emerges as a key regulatory factor in human cancers through diverse molecular mechanisms and clinical implications.Discover oncology · 2025Review
- Review
- Lysophosphatidate Promotes Sphingosine 1-Phosphate Metabolism and Signaling: Implications for Breast Cancer and Doxorubicin Resistance.Cell biochemistry and biophysics · 2021Article
- Evaluation of serum ATX and LPA as potential diagnostic biomarkers in patients with pancreatic cancer.BMC gastroenterology · 2021Article
- Lysophosphatidic Acid-Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase.Frontiers in pharmacology · 2021Article
- The role of sphingosine-1-phosphate in inflammation and cancer progression.Cancer science · 2018Review
- Lysophosphatidic Acid Signaling Axis Mediates Ceramide 1-Phosphate-Induced Proliferation of C2C12 Myoblasts.International journal of molecular sciences · 2018Article
- Resolvins and omega three polyunsaturated fatty acids: Clinical implications in inflammatory diseases and cancer.World journal of clinical cases · 2016Review
- Mesenchymal cell interaction with ovarian cancer cells induces a background dependent pro-metastatic transcriptomic profile.Journal of translational medicine · 2014Article
- Lysophosphatidic acid stimulates activation of focal adhesion kinase and paxillin and promotes cell motility, via LPA1-3, in human pancreatic cancer.Digestive diseases and sciences · 2013Article
- Migration of gastric cancer cells in response to lysophosphatidic acid is mediated by LPA receptor 2.Oncology letters · 2013Article
- Sphingosine kinase 1 in cancer.Advances in cancer research · 2013Review
- The expression of TMPRSS4 and Erk1 correlates with metastasis and poor prognosis in Chinese patients with gastric cancer.PloS one · 2013Article
- The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis.Lymphatic research and biology · 2012Review
- Twofer anti-vascular therapy targeting sphingosine-1-phosphate for breast cancer.Gland surgery · 2012Article
- Toward an integrative analysis of the tumor microenvironment in ovarian epithelial carcinoma.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2012Article
- Is T790M mutation the key in development of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)?Journal of thoracic disease · 2011Article
- Lysophosphatidic acid receptor agonists and antagonists (WO2010051053).Expert opinion on therapeutic patents · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
In MKN1 gastric cancer cells, lysophosphatidic acid (LPA) upregulates expression of sphingosine kinase 1 (SphK1) and its downregulation or inhibition suppresses LPA mediated proliferation. Although LPA activates numerous signaling pathways downstream of its receptors, including extracellular-signal-regulated kinase 1/2, p38, JNK, and Akt, and the transactivation of the epidermal growth factor receptor, pharmacological and molecular approaches demonstrated that only activation of ERK1, in addition to the CCAAT/enhancer-binding protein β transcription factor, is involved in transcriptional upregulation of SphK1 by LPA. Our data implicate ERK1 as an important mediator of LPA signaling leading to upregulation of SphK1 and point to SphK1 and sphingosine-1-phosphate production as potential therapeutic targets in gastric cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.