ArticleJournal of biomedical science2010
Taurine reduces ER stress in C. elegans.
Article in Journal of biomedical science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Caloric Restriction and Dietary Taurine Regulate Taurine Homeostasis Through Distinct Tissue-Specific Mechanisms in Mice.Molecular nutrition & food research · 2026Article
- Glutathione Contributes to Caloric Restriction-Triggered Shift in Taurine Homeostasis.Nutrients · 2025Article
- Article
- Endogenous fluorescent reporters for heat shock proteins are not detectable after stress induction.microPublication biology · 2024Article
- Exploring diabesity pathophysiology through proteomic analysis usingFrontiers in endocrinology · 2024Article
- Article
- In Vivo and In Vitro Assays Evaluating the Biological Activity of Taurine, Glucose and Energetic Beverages.Molecules (Basel, Switzerland) · 2021Article
- In vitro aggregating β-lactamase-polyQ chimeras do not induce toxic effects in an in vivo Caenorhabditis elegans model.Journal of negative results in biomedicine · 2017Article
- Article
- The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity.Scientific reports · 2013Article
- Increased transsulfuration mediates longevity and dietary restriction in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundER stress is a strong indicator of whether or not a cell is undergoing physiological stress. C. elegans is a practical system of characterizing the effect of ER stress at the in vivo or organismal level.
methodsThis study characterized taurine's anti-ER stress potential employing western blotting on ER stress markers and assays of motility, lifespan comparison, and fecundity measurement.
resultsWhen treated with tunicamycin, C. elegans showed the typical ER stress symptoms. It showed a higher expression of hsp-70 and skn-1 than the non-treated control. Survivorship significantly decreased under tunicamycin treatment, and the offspring number also decreased. During the synchronized culture under ER stress conditions, the C. elegans showed early signs of aging especially between L3 and L4 within their life span, along with lowered motility. The worms, however, showed a positive response to the taurine treatment under ER stress conditions.
conclusionsWhen C. elegans were treated with taurine before or after the tunicamycin treatment, they showed a less severe level of ER stress, including an enhanced survivorship, increased motility, and augmented fecundity. Taken together, these results strongly indicate that taurine works positively to cope with ER stress from the organismal perspective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.