ArticleJournal of biomedical science2010
Neuroprotection by taurine in ethanol-induced apoptosis in the developing cerebellum.
Article in Journal of biomedical science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Integrated Transcriptomics and Metabolomics Reveal Changes in Cell Homeostasis and Energy Metabolism inInternational journal of molecular sciences · 2024Article
- Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes.Nutrients · 2022Review
- Differences Between Physiological and Pharmacological Actions of Taurine.Advances in experimental medicine and biology · 2022Article
- Metabolomics Applied to Cord Serum in Preeclampsia Newborns: Implications for Neonatal Outcomes.Frontiers in pediatrics · 2022Article
- The Role of Taurine in Mitochondria Health: More Than Just an Antioxidant.Molecules (Basel, Switzerland) · 2021Review
- New solutions for old challenges in glaucoma treatment: is taurine an option to consider?Neural regeneration research · 2021Article
- Serum metabolomic patterns in young patients with ischemic stroke: a case study.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms.Redox biology · 2019Review
- Taurine protects against retinal and optic nerve damage induced by endothelin-1 in ratsNeural regeneration research · 2018Article
- Metabolic assessment of a migraine model using relaxation-enhancedMagnetic resonance in medicine · 2018Article
- Acute effect of Ethanol and Taurine on frontal cortex absolute beta power before and after exercise.PloS one · 2018Article
- Gut Microbiota and Relevant Metabolites Analysis in Alcohol Dependent Mice.Frontiers in microbiology · 2018Article
- Taurine ameliorated thyroid function in rats co-administered with chlorpyrifos and lead.Veterinary research communications · 2016Article
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage.Molecular neurobiology · 2015Article
- Choline Ameliorates Deficits in Balance Caused by Acute Neonatal Ethanol Exposure.Cerebellum (London, England) · 2015Article
- Apoptosis of Purkinje and granular cells of the cerebellum following chronic ethanol intake.Cerebellum (London, England) · 2014Article
- Activation of liver X receptor is protective against ethanol-induced developmental impairment of Bergmann glia and Purkinje neurons in the mouse cerebellum.Molecular neurobiology · 2014Article
- Cellular commitment in the developing cerebellum.Frontiers in cellular neuroscience · 2014Review
- Long-lasting neural circuit dysfunction following developmental ethanol exposure.Brain sciences · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute ethanol administration leads to massive apoptotic neurodegeneration in the developing central nervous system. We studied whether taurine is neuroprotective in ethanol-induced apoptosis in the mouse cerebellum during the postnatal period.
methodsThe mice were divided into three groups: ethanol-treated, ethanol+taurine-treated and controls. Ethanol (20% solution) was administered subcutaneously at a total dose of 5 g/kg (2.5 g/kg at time 1 h and 2.5 g/kg at 3 h) to the ethanol and ethanol+taurine groups. The ethanol+taurine group also received two injections of taurine (1 g/kg each, at time zero and at 4 h). To estimate apoptosis, immunostaining for activated caspase-3 and TUNEL staining were made in the mid-sagittal sections containing lobules I-X of the cerebellar vermis at 12 or 8 hours after the first taurine injection. Changes in the blood taurine level were monitored at each hour by reverse-phase high-performance liquid chromatography (HPLC).
resultsEthanol administration induced apoptosis of Purkinje cells on P4 in all cerebellar lobules, most extensively in lobules IX and X, and on P7 increased the number of activated caspase-3-immunoreactive and TUNEL-positive cells in the internal layer of the cerebellum. Administration of taurine significantly decreased the number of activated caspase-3-immunoreactive and TUNEL-positive cells in the internal layer of the cerebellum on P7, but had no effect on Purkinje cells in P4 mice. The high initial taurine concentration in blood of the ethanol+taurine group diminished dramatically during the experiment, not being different at 13 h from that in the controls.
conclusionsWe conclude that the neuroprotective action of taurine is not straightforward and seems to be different in different types of neurons and/or requires prolonged maintenance of the high taurine concentration in blood plasma.
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