ArticleLipids in health and disease2010
The assessment of carotid intima media thickness and serum paraoxonase-1 activity in Helicobacter pylori positive subjects.
Article in Lipids in health and disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Association between Helicobacter Pylori infection and stroke: a meta-analysis of 273,135 patients.Journal of neurology · 2021Pooled it
- Associations of the PON1 rs854560 polymorphism with plasma lipid levels: a meta-analysis.Lipids in health and disease · 2018Pooled it
- Helicobacter pylori components increase the severity of metabolic syndrome and its hepatic manifestations induced by a high fat diet.Scientific reports · 2024Article
- Searching for serum biomarkers linking coronary heart disease and Helicobacter pylori infection using infrared spectroscopy and artificial neural networks.Scientific reports · 2022Article
- High-density lipoprotein, low-density lipoprotein and triglyceride levels and upper gastrointestinal cancers risk: a trans-ancestry Mendelian randomization study.European journal of clinical nutrition · 2022Article
- Accumulation of Deleterious Effects in Gastric Epithelial Cells and Vascular Endothelial Cells In Vitro in the Milieu ofInternational journal of molecular sciences · 2022Article
- Antibodies towards TVLLPVIFF Amino Acid Sequence of TNF Receptor Induced byJournal of clinical medicine · 2022Article
- No evidence for a causal link betweenFrontiers in microbiology · 2022Article
- Article
- Association between Helicobacter pylori infection and carotid atherosclerosis in Chinese adults.Atherosclerosis plus · 2021Article
- On the Role of Paraoxonase-1 and Chemokine Ligand 2 (C-C motif) in Metabolic Alterations Linked to Inflammation and Disease. A 2021 Update.Biomolecules · 2021Review
- Relationship BetweenInternational journal of general medicine · 2021Review
- Relationship BetweenDiabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Paraoxonases Activities and Polymorphisms in Elderly and Old-Age Diseases: An Overview.Antioxidants (Basel, Switzerland) · 2019Review
- Association between Helicobacter pylori infection and non-alcoholic fatty liver disease in North Chinese: a cross-sectional study.Scientific reports · 2019Article
- Helicobacter pylori infection is not related to increased carotid intima-media thickness in general population.Scientific reports · 2018Article
- Effect of Losartan in Complete Freund's Adjuvant -Induced Arthritis in Rats.Iranian journal of pharmaceutical research : IJPR · 2018Article
- Assessment of the Relationship between Carotid Intima-Media Thickening and Early-Stage Diabetic Kidney Disease Coupled withDisease markers · 2018Article
- Molecular mimicry inWorld journal of gastroenterology · 2017Review
- The Correlation and Risk Factors between Carotid Intima-Media Thickening and Alcoholic Liver Disease Coupled with Helicobacter pylori Infection.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of inflammation in the pathogenesis and progression of atherosclerosis has been increasingly discussed. Although the seroepidemiological studies have suggested a relationship between Helicobacter pylori (H. pylori) infection and atherosclerosis; the issue is still controversial. It is well known that abnormal lipid profil is related to atherosclerosis and the measurement of carotid-intima media thickness (CIMT) is one of the surrogate marker of atherosclerosis. The serum concentration of high-density lipoprotein (HDL-C) has been known to have an inverse correlation with the development of atherosclerosis. Paraoxonase-1 (PON1) is a major anti-atherosclerotic component of HDL-C. PON1 activity is related to lipid peroxidation and prospective cardiovascular risk. The aim of this study was to investigate CIMT and serum PON1 activities along with lipid parameters in H. pylori positive and negative subjects.
methodsThirty H. pylori positive subjects and thirty-one negative subjects were enrolled. H. pylori infection was diagnosed by the presence of positivity of stool H. pylori antigen test or Carbon 14 labeled urea breath test. Serum PON1 activity was measured spectrophotometrically. Traditional cardiovascular risk factors were investigated and laboratory analysis included measurement of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We assessed CIMT by high-resolution ultrasound of both common carotid arteries.
resultsWe found that the mean and maximum values of right and overall CIMT in H. pylori positive subjects were significantly thicker than those of H. pylori negative subjects. There was no significant differences in serum HDL-C, LDL-C, TC levels and TC/HDL-C ratios between two groups. Serum TG levels of H. pylori positive subjects were significantly higher than those of H. pylori negative subjects (p = 0.014). We found that PON1 activities were significantly lower in H. pylori positive subjects compared with negative subjects. No significantly correlation was observed between PON1 and CIMT values.
conclusionsThere is an increase in CIMT values in patients with H. pylori positive compared to H. pylori negative subjects. PON1 activity decrease significantly in H. pylori positive subjects. However, an association between PON1 and CIMT was not found. These data indicated that H. pylori may have a role in atherosclerotic processes, however, further studies are needed to evaluate the exact mechanisms.
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