ArticleNeuropsychology2010
Testing covariates of Type 2 diabetes-cognition associations in older adults: moderating or mediating effects?
Article in Neuropsychology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between Depressive Symptoms and Cognitive Function in Persons with Diabetes Mellitus: A Systematic Review.PloS one · 2016Pooled it
- Effect of short-term glycemic control and physical activity on health-related quality of life among type 2 diabetes receiving care in a tertiary health facility in Ogun State, Nigeria: a cross-sectional study.The Pan African medical journal · 2023Article
- Cognitive Reserve and Executive Functions in Adults with Type 2 Diabetes.Journal of diabetes research · 2020Article
- Effects of adiposity and metabolic dysfunction on cognition: A review.Physiology & behavior · 2019Review
- Alzheimer's Genetic Risk Intensifies Neurocognitive Slowing Associated with Diabetes in Non-Demented Older Adults.Alzheimer's & dementia (Amsterdam, Netherlands) · 2015Article
- The synergistic effects of HIV, diabetes, and aging on cognition: implications for practice and research.The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses · 2014Review
- IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults.Neurobiology of aging · 2013Article
- Effects of hypertension and diabetes on sentence comprehension in aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2013Article
- Tracking cognition-health changes from 55 to 95 years of age.The journals of gerontology. Series B, Psychological sciences and social sciences · 2011Article
- Linking biological and cognitive aging: toward improving characterizations of developmental time.The journals of gerontology. Series B, Psychological sciences and social sciences · 2011Article
- Are neurocognitive speed and inconsistency similarly affected in type 2 diabetes?Journal of clinical and experimental neuropsychology · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe general goal of this study was to advance our understanding of Type 2 diabetes (T2D)-cognition relationships in older adults by linking and testing comprehensive sets of potential moderators, potential mediators, and multiple cognitive outcomes.
methodWe identified in the literature 13 health-related (but T2D-distal) potential covariates, representing four informal domains (i.e., biological vitality, personal affect, subjective health, lifestyle activities). Cross-sectional data from the Victoria Longitudinal Study (age range = 53-90 years; n = 41 T2D and n = 458 control participants) were used. We first examined whether any of the 13 potential covariates influenced T2D-cognition associations, as measured by a comprehensive neuropsychological battery (15 measures). Next, using standard regression-based moderator and mediator analyses, we systematically tested whether the identified covariates would significantly alter observed T2D-cognition relationships.
resultsSix potential covariates were found to be sensitive to T2D associations with performance on seven cognitive measures. Three factors (systolic blood pressure, gait-balance composite, subjective health) were significant mediators. Each mediated multiple cognitive outcomes, especially measures of neurocognitive speed, executive functioning, and episodic memory.
conclusionsOur findings offer a relatively comprehensive perspective of T2D-related cognitive deficits, comorbidities, and modulating influences. The implications for future research reach across several fields of study and application. These include (1) neuropsychological research on neural and biological bases of T2D-related cognitive decline, (2) clinical research on intervention and treatment strategies, and (3) larger-scale longitudinal studies examining the potential multilateral and dynamic relationships among T2D status, related comorbidities, and cognitive outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.