Evidence map›Paper›PMID 20804202›Full record

ReviewJournal of medicinal chemistry2010

Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore.

Fraser F Fleming, Lihua Yao, P C Ravikumar, Lee Funk, Brian C Shook

Abstract readReview
In one paragraph

Review in Journal of medicinal chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 264 papers.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

264 citing papers in PubMed.

  1. Review
  2. Recent advances in [Nuclear medicine and biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Catalyst-Free Cyanation of Arenes by Acetonitrile in a Plasma-Liquid Microreactor.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  7. Photochemical Cascade Nitrile Activation via a Carbene-Nitrene Relay.Angewandte Chemie (International ed. in English) · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Sulfonyl-PYBOX/ErClNature communications · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Organic process research & development · 2026
    Article
  19. Article
  20. Article

204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fraser F FlemingDepartment of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282-1530, USA. flemingf@duq.edu
Lihua Yao
P C Ravikumar
Lee Funk
Brian C Shook

Funding

Nitrile-Containing Decalins in MedicineR15AI051352 · NIAID · DUQUESNE UNIVERSITY · PI BEAVER, BRUCE · 2002 to 2012
$1.1M
NIAID NIH HHS 2R15AI-051352-03NIAID NIH HHS R15 AI051352
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAnti-HIV AgentsCardiovascular AgentsCathepsinsCentral Nervous System AgentsCrystallography, X-RayDipeptidyl-Peptidase IV InhibitorsDrug DiscoveryHumansModels, MolecularMolecular StructureNitrilesStructure-Activity RelationshipXanthine OxidaseAnti-HIV AgentsCardiovascular AgentsCathepsinsCentral Nervous System AgentsDipeptidyl-Peptidase IV InhibitorsNitrilesXanthine Oxidase

Identifiers

PMID20804202
PMCPMC2988972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.