ArticleJournal of Zhejiang University. Science. B2010
Comparative features of colorectal and gastric cancers with microsatellite instability in Chinese patients.
Article in Journal of Zhejiang University. Science. B, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Head-to-head comparative study: evaluating three panels for MSI-PCR testing in patients with colorectal and gastric cancer.Journal of clinical pathology · 2024Article
- Low incidence of microsatellite instability in gastric cancers and its association with the clinicopathological characteristics: a comparative study.Scientific reports · 2023Article
- Identification of RNF150 as the hub gene associated with microsatellite instability in gastric cancer.Scientific reports · 2023Article
- High Frequency of Microsatellite Instability among Non-Metastatic Gastric Cancer.International journal of hematology-oncology and stem cell research · 2022Article
- Microsatellite instability in Chinese gastric cancer and its correlation with clinical characteristics.Journal of gastrointestinal oncology · 2021Article
- Incidence and detection of high microsatellite instability in colorectal cancer in a Chinese population: a meta-analysis.Journal of gastrointestinal oncology · 2020Article
- Microsatellite Instability and Life Style Factors in Sporadic Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Expanding the Scope of Immunotherapy in Colorectal Cancer: Current Clinical Approaches and Future Directions.BioMed research international · 2020Review
- Clinical significance ofWorld journal of gastrointestinal oncology · 2019Article
- Deficient mismatch repair andPeerJ · 2018Article
- Mismatch Repair Proteins and Microsatellite Instability in Colorectal Carcinoma (MLH1, MSH2, MSH6 and PMS2): Histopathological and Immunohistochemical Study.Open access Macedonian journal of medical sciences · 2017Article
- Prediction of biological behavior and prognosis of colorectal cancer patients by tumor MSI/MMR in the Chinese population.OncoTargets and therapy · 2016Article
- KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients.World journal of gastroenterology · 2015Article
- Lynch syndrome-associated neoplasms: a discussion on histopathology and immunohistochemistry.Familial cancer · 2013Review
- Novel DNA variants and mutation frequencies of hMLH1 and hMSH2 genes in colorectal cancer in the Northeast China population.PloS one · 2013Article
- Microsatellite instability testing in Korean patients with colorectal cancer.Familial cancer · 2012Article
- Association between methylation in mismatch repair genes, V600E BRAF mutation and microsatellite instability in colorectal cancer patients.Molecular biology reports · 2012Article
- The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran.Gastroenterology research and practice · 2012Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to determine the unique and universal features of microsatellite instability-high (MSI-H) colorectal cancer (CRC) and MSI-H gastric cancer (GC) in the Chinese population.
methodsA new panel of mononucleotide MSI markers, BAT25, BAT26, NR21, NR24, and MONO-27, was used to define MSI status in 303 CRC and 288 GC subjects. Clinicopathological features of both types of MSI-H tumors were analyzed. Methylation analysis in the hMLH1 promoter region by methylation specific polymerase chain reaction (PCR) and mutation detection of hMSH2/hMLH1 genes by denaturing high-performance liquid chromatography (DHPLC) were carried out simultaneously.
resultsMSI-H CRCs and MSI-H GCs account for 11.9% and 8.0% of unselected sporadic CRCs and GCs, respectively. MSI-H CRCs are strongly characterized by early onset, right-side location, low differentiation, mucinous tumor, less infiltration, less lymphatic metastasis, and more often familial tumor. MSI-H GCs only showed site preference for the antrum and less lymphatic metastasis. Genetic and epigenetic analyses were positive in 6/36 MSI-H CRCs and 0/23 MSI-H GCs with pathological mutation in major mismatch repair genes, and in 7/36 MSI-H CRCs and 18/23 MSI-H GCs with methylated hMLH1 promoter (P<0.01), respectively.
conclusionsAlthough there are many differences in the genetic basis and clinicopathological features between MSI-H CRC and MSI-H GC, when compared with their microsatellite stable (MSS) counterparts, site preference and lymphatic metastasis are features common to both types of MSI-H tumors.
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