ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Expression, functional, and structural analysis of proteins critical for otoconia development.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05863949 (STOP Vertigo), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
STOP Vertigo: Supplementation of Vitamin D for Termination of Recurrences From Benign Paroxysmal Positional Vertigo
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- Involvement of Dmp1 in the Precise Regulation of Hair Bundle Formation in the Developing Cochlea.Biology · 2023Article
- The Role of Intrinsically Disordered Proteins in Liquid-Liquid Phase Separation during Calcium Carbonate Biomineralization.Biomolecules · 2022Review
- Vitamin D Insufficiency/Deficiency in Patients with Recurrent Benign Paroxysmal Positional Vertigo.The journal of international advanced otology · 2022Article
- Development and evolution of the vestibular apparatuses of the inner ear.Journal of anatomy · 2021Review
- Relation between vitamin D deficiency and benign paroxysmal positional vertigo.Scientific reports · 2021Article
- Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics.Cell reports · 2021Article
- Whole-Genome Sequencing and Genome-Wide Studies of Spiny Head Croaker (Frontiers in genetics · 2021Article
- Functional cooperation between two otoconial proteins Oc90 and Nox3.Journal of vestibular research : equilibrium & orientation · 2021Article
- Effect of Vitamin D Injection in Recurrent Benign Paroxysmal Positional Vertigo with Vitamin D Deficiency.International archives of otorhinolaryngology · 2020Article
- Otopetrin-2 Immunolocalization in the Human Macula Utricle.The Annals of otology, rhinology, and laryngology · 2019Article
- Characterization of spatial and temporal development of Type I and Type II hair cells in the mouse utricle using new cell-type-specific markers.Biology open · 2018Article
- Mechanism Underlying the Effects of Estrogen Deficiency on Otoconia.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Serum vitamin D and recurrent benign paroxysmal positional vertigo.Laryngoscope investigative otolaryngology · 2016Article
- Spatiotemporal differences in otoconial gene expression.Genesis (New York, N.Y. : 2000) · 2016Article
- Mechanisms of otoconia and otolith development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Effect of Otoconial Proteins Fetuin A, Osteopontin, and Otoconin 90 on the Nucleation and Growth of Calcite.Crystal growth & design · 2015Article
- Vitamin D deficiency and benign paroxysmal positioning vertigo.Medical hypotheses · 2013Article
- Matrix recruitment and calcium sequestration for spatial specific otoconia development.PloS one · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Otoconia, developed during late gestation and perinatal stages, couple mechanic force to the sensory hair cells in the vestibule for motion detection and bodily balance. In the present work, we have investigated whether compensatory deposition of another protein(s) may have taken place to partially alleviate the detrimental effects of Oc90 deletion by analyzing a comprehensive list of plausible candidates, and have found a drastic increase in the deposition of Sparc-like 1 (aka Sc1 or hevin) in Oc90 null versus wt otoconia. We show that such up-regulation is specific to Sc1, and that stable transfection of Oc90 and Sc1 full-length expression constructs in NIH/3T3 cells indeed promotes matrix calcification. Analysis and modeling of Oc90 and Sc1 protein structures show common features that may be critical requirements for the otoconial matrix backbone protein. Such information will serve as the foundation for future regenerative purposes.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.