Evidence map›Paper›PMID 20803321›Full record

ReviewCurrent HIV/AIDS reports2010

Drug treatment as HIV prevention: expanding treatment options.

David S Metzger, Yan Zhang

Abstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

David S MetzgerHIV/AIDS Prevention Research Division, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA. dsm@mail.med.upenn.edu
Yan Zhang
Penn Center for AIDS Research · USUniversity of Pennsylvania · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
HIV PREVENTION TRIAL UNITU01AI048014 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI METZGER, DAVID S · 2000 to 2006
$20.9M
Efficacy of Drug-HIV counseling among IDU at Methadone clinics in JakartaR01DA026344 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI METZGER, DAVID S · 2009 to 2012
$1.3M
NIAID NIH HHS 6-P30-AI-45008NIAID NIH HHS P30 AI045008NIAID NIH HHS U01 AI048014NIAID NIH HHS U01-AI-048014NIDA NIH HHS R01 DA026344NIDA NIH HHS R01-DA-026344-01A1
6 · The paper itself

Abstract

Research conducted during the first 20 years of the AIDS epidemic provided a solid foundation of data supporting methadone treatment as HIV prevention. Drug users in methadone treatment were consistently found to reduce the frequency of drug use, risk behaviors, and infections. These data have been consistent over time and across cultural settings and have been used to promote the expansion of drug treatment as a prevention intervention. More recently, data have emerged suggesting the prevention potential of medication-assisted treatments other than methadone (buprenorphine/naloxone and naltrexone). Still, with a few notable exceptions, global drug treatment coverage for opiate injectors remains remarkably low and only a few treatment interventions for stimulant use have shown efficacy in reducing HIV risk. Importantly, more recent data provide support for the role of drug treatment programs in improving access and adherence to antiretroviral treatment and that injection drug users in substance abuse treatment are more likely to achieve sustained viral suppression. While important challenges remain in maximizing its impact, the scientific literature provides strong evidence of the efficacy of drug treatment as an HIV prevention strategy.

Indexed as

Opiate Substitution TreatmentAlcoholismBuprenorphineClinical ProtocolsDrug UsersHealth PromotionHIV InfectionsHumansMethadoneNaltrexoneRisk Reduction BehaviorRisk-TakingSubstance Abuse, IntravenousSubstance-Related DisordersBuprenorphineMethadoneNaltrexone

Identifiers

PMID20803321
PMCPMC3155767
OpenAlexW2094335914

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.