ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2010
Radiobiological comparison of hypofractionated accelerated partial-breast irradiation (APBI) and single-dose intraoperative radiotherapy (IORT) with 50-kV X-rays.
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01440010 (TARGeted Intraoperative radioTherapy With the INTRABEAM-System as an Advanced Boost in Patients With Breast Cancer - A Quality Control Registry in Germany), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TARGeted Intraoperative radioTherapy With the INTRABEAM-System as an Advanced Boost in Patients With Breast Cancer - A Quality Control Registry in Germany (TARGIT BQR)
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Impact of intraoperative margin optimization strategies compared to standard breast-conserving surgery on oncologic outcomes: a systematic review and meta-analysis of randomized and prospective trials.World journal of surgical oncology · 2025Pooled it
- Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial.BMJ (Clinical research ed.) · 2020Trial
- Trial
- INTRAGO: intraoperative radiotherapy in glioblastoma multiforme—a phase I/II dose escalation study.BMC cancer · 2014Trial
- Effect of a combined surgery, re-irradiation and hyperthermia therapy on local control rate in radio-induced angiosarcoma of the chest wall.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2013Trial
- Long term effectiveness of intraoperative radiotherapy given as a boost in adjuvant treatment for oral cavity cancers.Scientific reports · 2025Article
- Early Outcome, Cosmetic Result and Tolerability of an IOERT-Boost Prior to Adjuvant Whole-Breast Irradiation.Cancers · 2022Article
- Present state and issues in IORT Physics.Radiation oncology (London, England) · 2017Review
- Intraoperative radiotherapy (IORT) as boost in breast cancer.Radiation oncology (London, England) · 2017Review
- Biology of high single doses of IORT: RBE, 5 R's, and other biological aspects.Radiation oncology (London, England) · 2017Review
- Immunotherapy Combined with Large Fractions of Radiotherapy: Stereotactic Radiosurgery for Brain Metastases-Implications for Intraoperative Radiotherapy after Resection.Frontiers in oncology · 2017Review
- Accelerated Partial Breast Irradiation in Clinical Practice.Breast care (Basel, Switzerland) · 2015Review
- Intraoperative Period and Breast Cancer: Review.The journal of breast health · 2014Review
- Boost IORT in Breast Cancer: Body of Evidence.International journal of breast cancer · 2014Review
- [Rules and regulations applying to incidents in radiotherapy].Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2012Article
- Can the risk of secondary cancer induction after breast conserving therapy be reduced using intraoperative radiotherapy (IORT) with low-energy x-rays?Radiation oncology (London, England) · 2011Article
- [Hemangiosarcoma after breast-conserving therapy of breast cancer: report of four cases with molecular genetic diagnosis and literature review].Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2011Review
- Topical use of a silymarin-based preparation to prevent radiodermatitis : results of a prospective study in breast cancer patients.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIntraoperative radiotherapy (IORT) of the tumor bed in early breast cancer is presently performed with a single dose of 50-kV X-rays from a miniaturized X-ray machine using spherical applicators. The purpose was to model the biological effect of hypofractionated accelerated partial-breast irradiation (APBI) with ten fractions. MATERIAL AND
methodsThe relative biologic effectiveness (RBE) was estimated from the linear-quadratic (L-Q) formalism including repair of sublethal damage or assuming a constant RBE = 1.2-1.5. The radial distribution of biological effect was assessed from clinical dose-response curves. In accordance with clinical convention, the dose for APBI was prescribed at 1 cm depth in the tumor bed, whereas for IORT it was prescribed at the applicator surface.
resultsThe fraction size was fitted to give the same risk of late normal-tissue reaction (fibrosis) as single-dose IORT with a maximum dose of 20 Gy. The isoeffective fraction size at 1 cm depth varied between 1.01 Gy for RBE estimated from the L-Q model and 1.64 Gy for constant RBE. The applicator size and dose prescription point influenced the radial dose distribution. The "sphere of equivalence" within which the risk for local recurrence is the same for whole-breast radiotherapy was predicted to extend to 11-15 mm distance from the applicator for alpha/beta = 10 Gy and 9-13 mm for alpha/beta = 4 Gy for hypofractionated APBI, representing an increase of the sphere of equivalence by 2.5-6 mm relative to single-dose IORT.
conclusionAn increase of the therapeutic window with hypofractionated APBI relative to single-dose IORT should be feasible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.