ArticleEuropean radiology2011
Derivation of a T2-weighted MRI total colonic inflammation score (TCIS) for assessment of patients with severe acute inflammatory colitis-a preliminary study.
Article in European radiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Systematic Review: Outcome Prediction in Acute Severe Ulcerative Colitis.Gastro hep advances · 2024Review
- Role of abbreviated non-contrast-enhanced MR-enterography in the evaluation of Crohn's disease activity and complications as an alternative for full protocol contrast-enhanced study: A systematic review and meta-analysis.Research in diagnostic and interventional imaging · 2023Article
- MR enterography grading of pediatric ileocolonic Crohn disease activity based on a single bowel segment.La Radiologia medica · 2021Article
- CT-Visualized Colonic Mural Stratification Independently Predicts the Need for Medical or Surgical Rescue Therapy in Hospitalized Ulcerative Colitis Patients.Digestive diseases and sciences · 2019Article
- Detecting inflammation in inflammatory bowel disease - how does ultrasound compare to magnetic resonance enterography using standardised scoring systems?Pediatric radiology · 2018Article
- Colonic inflammation in pediatric inflammatory bowel disease: detection with magnetic resonance enterography.Pediatric radiology · 2017Article
- Review article: dose optimisation of infliximab for acute severe ulcerative colitis.Alimentary pharmacology & therapeutics · 2017Review
- Acute severe ulcerative colitis: from pathophysiology to clinical management.Nature reviews. Gastroenterology & hepatology · 2016Review
- Detecting inflammation in the unprepared pediatric colon - how reliable is magnetic resonance enterography?Pediatric radiology · 2016Article
- Accuracy of abdominal ultrasound and MRI for detection of Crohn disease and ulcerative colitis in children.Pediatric radiology · 2014Article
- Differences in the location and activity of intestinal Crohn's disease lesions between adult and paediatric patients detected with MRI.European radiology · 2012Article
- Quantitative MRI of colonic mural enhancement: segmental differences exist in endoscopically proven normal colon.The British journal of radiology · 2012Article
- The future developments in gastrointestinal radiology.Frontline gastroenterology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo derive an MRI score for assessing severity, therapeutic response and prognosis in acute severe inflammatory colitis.
methodsTwenty-one patients with acute severe colitis underwent colonic MRI after admission and again (n = 16) after median 5 days of treatment. Using T2-weighted images, two radiologists in consensus graded segmental haustral loss, mesenteric and mural oedema, mural thickness, and small bowel and colonic dilatation producing a total colonic inflammatory score (TCIS, range 6-95). Pre- and post-treatment TCIS were compared, and correlated with CRP, stool frequency, and number of inpatient days (therapeutic response marker). Questionnaire assessment of patient worry, satisfaction and discomfort graded 1 (bad) to 7 (good) was administered
resultsAdmission TCIS correlated significantly with CRP (Kendall's tau=0.45, 95% confidence interval [CI] 0.11-0.79, p = 0.006), and stool frequency (Kendall's tau 0.39, 95% CI 0.14-0.64, p = 0.02). TCIS fell after treatment (median [22 range 15-31]) to median 20 [range 8-25], p = 0.01. Admission TCIS but not CRP or stool frequency was correlated with length of inpatient stay (Kendall's tau 0.40, 95% CI 0.11-0.69, p = 0.02). Patients reported some discomfort (median score 4) during MRI.
conclusionsMRI TCIS falls after therapy, correlates with existing markers of disease severity, and in comparison may better predict therapeutic response.
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