ReviewCancer metastasis reviews2010
Tomato-based food products for prostate cancer prevention: what have we learned?
Review in Cancer metastasis reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Dried Fruit Intake and Cancer: A Systematic Review of Observational Studies.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Pooled it
- Dietary factors and risk for advanced prostate cancer.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2014Pooled it
- Lycopene for the prevention of prostate cancer.The Cochrane database of systematic reviews · 2011Pooled it
- Genome-wide study of salt tolerance in USDA tomato germplasm at seedling stage.Scientific reports · 2025Article
- Nanopriming with zinc oxide nanoparticle boosts seed vigour, photosynthesis, osmolytes accumulation and antioxidant activity in tomato.Scientific reports · 2025Article
- Mitochondria at the Crossroads: Linking the Mediterranean Diet to Metabolic Health and Non-Pharmacological Approaches to NAFLD.Nutrients · 2025Review
- Phytochemical and Biological Biodiversity of Tomato (Mini reviews in medicinal chemistry · 2025Review
- Emerging functions of lycopene in the management of digestive premalignant lesions.Frontiers in pharmacology · 2024Review
- Orchestration of miRNA Patterns by Testosterone and Dietary Tomato Carotenoids during Early Prostate Carcinogenesis in TRAMP Mice.The Journal of nutrition · 2023Article
- Exogenous Application of Calcium Ameliorates Salinity Stress Tolerance of Tomato (Antioxidants (Basel, Switzerland) · 2023Article
- Effect of foaming parameters on the physical and phytochemical properties of tomato powder.Food science and biotechnology · 2022Article
- Systematic analysis of the sugar accumulation mechanism in sucrose- and hexose- accumulating cherry tomato fruits.BMC plant biology · 2022Article
- Tomatoes, Lycopene, and Prostate Cancer: What Have We Learned from Experimental Models?The Journal of nutrition · 2022Review
- Effect of Elevated Carbon Dioxide Exposure on Nutrition-Health Properties of Micro-Tom Tomatoes.Molecules (Basel, Switzerland) · 2022Article
- Foods of the Mediterranean diet: tomato, olives, chili pepper, wheat flour and wheat germ.Journal of preventive medicine and hygiene · 2022Review
- The Effect of Sodium Total Substitution on the Quality Characteristics of Green Pickled Tomatoes (Molecules (Basel, Switzerland) · 2022Article
- A high consumption of tomato and lycopene is associated with a lower risk of cancer mortality: results from a multi-ethnic cohort.Public health nutrition · 2020Article
- The Effects of a Microorganisms-Based Commercial Product on the Morphological, Biochemical and Yield of Tomato Plants under Two Different Water Regimes.Microorganisms · 2019Article
- Comparative Analysis of Lycopene Content from Different Tomato-Based Food Products on the Cellular Activity of Prostate Cancer Cell Lines.Foods (Basel, Switzerland) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Evidence derived from a vast array of laboratory studies and epidemiological investigations have implicated diets rich in fruits and vegetables with a reduced risk of certain cancers. However, these approaches cannot demonstrate causal relationships and there is a paucity of randomized, controlled trials due to the difficulties involved with executing studies of food and behavioral change. Rather than pursuing the definitive intervention trials that are necessary, the thrust of research in recent decades has been driven by a reductionist approach focusing upon the identification of bioactive components in fruits and vegetables with the subsequent development of single agents using a pharmacologic approach. At this point in time, there are no chemopreventive strategies that are standard of care in medical practice that have resulted from this approach. This review describes an alternative approach focusing upon development of tomato-based food products for human clinical trials targeting cancer prevention and as an adjunct to therapy. Tomatoes are a source of bioactive phytochemicals and are widely consumed. The phytochemical pattern of tomato products can be manipulated to optimize anticancer activity through genetics, horticultural techniques, and food processing. The opportunity to develop a highly consistent tomato-based food product rich in anticancer phytochemicals for clinical trials targeting specific cancers, particularly the prostate, necessitates the interactive transdisciplinary research efforts of horticulturalists, food technologists, cancer biologists, and clinical translational investigators.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.