ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2010
Properties of cannabinoid-dependent long-term depression in the leech.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Role of Concentration in Opposing Effects of Anandamide on Nociceptive Synapses versus Non-nociceptive Synapses.eNeuro · 2026Article
- Non-synaptic Plasticity in Leech Touch Cells.Frontiers in physiology · 2019Article
- Endocannabinoid-mediated potentiation of nonnociceptive synapses contributes to behavioral sensitization.Journal of neurophysiology · 2018Article
- Pentylenetetrazol-induced seizure-like behavior and neural hyperactivity in the medicinal leech.Invertebrate neuroscience : IN · 2015Article
- Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated presynaptic and postsynaptic transcription and translation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The evolution and comparative neurobiology of endocannabinoid signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previously, a cannabinoid-dependent form of long-term depression (LTD) was discovered at the polysynaptic connection between the touch mechanosensory neuron and the S interneuron (Li and Burrell in J Comp Physiol A 195:831-841, 2009). In the present study, the physiological properties of this cannabinoid-dependent LTD were examined. Increases in intracellular calcium in the S interneuron are necessary for this form of LTD in this circuit. Calcium signals contributing to cannabinoid-dependent LTD are mediated by voltage-dependent calcium channel and release of calcium from intracellular stores. Inositol triphosphate receptors, but not ryanodine receptors, appear to mediate this store-released calcium signal. Cannabinoid-dependent LTD also requires activation of metabotropic serotonin receptors, possibly a serotonin type 2-like receptor. Finally, this form of LTD involves the stimulation of nitric oxide synthase and a decrease in cyclic adenosine monophosphate signaling, both of which appeared to be downstream of cannabinoid receptor activation. Based on these findings, the cellular signaling mechanisms of cannabinoid-dependent LTD in the leech are remarkably similar to vertebrate forms of cannabinoid-dependent synaptic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.