ArticleAnalytical and bioanalytical chemistry2010
Modeling the relative impact of capsular tissue effects on implanted glucose sensor time lag and signal attenuation.
Article in Analytical and bioanalytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Redundancy in Glucose Sensing: Enhanced Accuracy and Reliability of an Electrochemical Redundant Sensor for Continuous Glucose Monitoring.Journal of diabetes science and technology · 2016Trial
- Dynamic and living devices for overcoming fibrosis of implanted biomaterials.Bioengineering & translational medicine · 2026Review
- Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells.Nature biomedical engineering · 2023Article
- Continuous Glucose Monitoring Devices: Past, Present, and Future Focus on the History and Evolution of Technological Innovation.Journal of diabetes science and technology · 2021Review
- Charge Transfer and Biocompatibility Aspects in Conducting Polymer-Based Enzymatic Biosensors and Biofuel Cells.Nanomaterials (Basel, Switzerland) · 2021Review
- Monitoring with In Vivo Electrochemical Sensors: Navigating the Complexities of Blood and Tissue Reactivity.Sensors (Basel, Switzerland) · 2020Review
- A self-cleaning, mechanically robust membrane for minimizing the foreign body reaction: towards extending the lifetime of sub-Q glucose biosensors.Journal of materials science. Materials in medicine · 2019Article
- Influence of diabetes on the foreign body response to nitric oxide-releasing implants.Biomaterials · 2018Article
- Foreign Body Reaction to a Subcutaneously Implanted Self-Cleaning, Thermoresponsive Hydrogel Membrane for Glucose Biosensors.ACS biomaterials science & engineering · 2018Article
- Effect of sensor location on continuous intraperitoneal glucose sensing in an animal model.PloS one · 2018Article
- In Vivo Chemical Sensors: Role of Biocompatibility on Performance and Utility.Analytical chemistry · 2017Review
- Article
- Controlled release of biologics for the treatment of type 2 diabetes.Journal of controlled release : official journal of the Controlled Release Society · 2016Review
- Preliminary Evaluation of a Long-Term Intraperitoneal Glucose Sensor With Flushing Mechanism.Journal of diabetes science and technology · 2016Article
- Porous, Dexamethasone-loaded polyurethane coatings extend performance window of implantable glucose sensors in vivo.Acta biomaterialia · 2016Article
- Modeling the Physiological Factors Affecting Glucose Sensor Function in Vivo.Journal of diabetes science and technology · 2015Article
- Preclinical Performance Evaluation of Percutaneous Glucose Biosensors: Experimental Considerations and Recommendations.Journal of diabetes science and technology · 2015Article
- Macrophage embedded fibrin gels: an in vitro platform for assessing inflammation effects on implantable glucose sensors.Biomaterials · 2014Article
- Characterization of porous, dexamethasone-releasing polyurethane coatings for glucose sensors.Acta biomaterialia · 2014Article
- Role of vascular networks in extending glucose sensor function: Impact of angiogenesis and lymphangiogenesis on continuous glucose monitoring in vivo.Journal of biomedical materials research. Part A · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Little is known mechanistically about why implanted glucose sensors lag behind blood glucose levels in both the time to peak sensor response and the magnitude of peak sensor response. A mathematical model of glucose transport from capillaries through surrounding tissue to the sensor surface was constructed to address how different aspects of the tissue affect glucose transport to an implanted sensor. Physiologically relevant values of capsule diffusion coefficient, capsule porosity, cellular glucose consumption, capsule thickness, and subcutaneous vessel density were used as inputs to create simulated sensor traces that mimic experimental instances of time lag and concentration attenuation relative to a given blood glucose profile. Using logarithmic sensitivity analysis, each parameter was analyzed to study the effect of these variables on both lag and attenuation. Results identify capsule thickness as the strongest determinant of sensor time lag, while subcutaneous vessel density and capsule porosity had the largest effects on attenuation of glucose that reaches the sensor surface. These findings provide mechanistic insight for the rational design of sensor modifications that may alleviate the deleterious consequences of tissue effects on implanted sensor performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.