ArticleFrontiers in neuroenergetics2010
Vascular tone and neurovascular coupling: considerations toward an improved in vitro model.
Article in Frontiers in neuroenergetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Disparate Mechanical and Functional Properties of Spontaneously Hypertensive Rat and Spontaneously Hypertensive Heart Failure Rat Penetrating Arterioles.Journal of cardiovascular pharmacology · 2026Article
- Distinct neurochemical influences on fMRI response polarity in the striatum.Nature communications · 2024Article
- Putative neurochemical and cell type contributions to hemodynamic activity in the rodent caudate putamen.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Review
- Connexin and Pannexin Large-Pore Channels in Microcirculation and Neurovascular Coupling Function.International journal of molecular sciences · 2022Review
- Age-related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review.Psychophysiology · 2021Review
- The Neurovascular Unit Dysfunction in Alzheimer's Disease.International journal of molecular sciences · 2021Review
- A wireless, skin-interfaced biosensor for cerebral hemodynamic monitoring in pediatric care.Proceedings of the National Academy of Sciences of the United States of America · 2020Observational
- Article
- Vasodilator effects of sulforaphane in cerebral circulation: A critical role of endogenously produced hydrogen sulfide and arteriolar smooth muscle KJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- The Role of Brain Vasculature in Glioblastoma.Molecular neurobiology · 2019Review
- Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol.Neurosurgery · 2018Review
- Evidence that remodeling of insular cortex neurovascular unit contributes to hypertension-related sympathoexcitation.Physiological reports · 2017Article
- Article
- Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone.Neuroscience · 2016Review
- Development of Point of Care Testing Device for Neurovascular Coupling From Simultaneous Recording of EEG and NIRS During Anodal Transcranial Direct Current Stimulation.IEEE journal of translational engineering in health and medicine · 2015Article
- Organotypic brain slice cultures as a model to study angiogenesis of brain vessels.Frontiers in cell and developmental biology · 2015Article
- Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder?Neural plasticity · 2015Review
- Basal blood flow and autoregulation changes in the optic nerve of rhesus monkeys with idiopathic bilateral optic atrophy.Investigative ophthalmology & visual science · 2013Article
- Neurovascular imaging.Frontiers in neuroenergetics · 2012Article
- Purinergic mechanisms in gliovascular coupling.Seminars in cell & developmental biology · 2011Review
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1 author.
Funding
Abstract
Neurovascular research has made significant strides toward understanding how the brain neurovascular unit accomplishes rapid and spatial increases in blood flow following neuronal activation. Among the experimental models used, the in vitro brain slice preparation provides unique information revealing the potential signals and cellular mechanisms involved in functional hyperemia. The most crucial limitation of this model, however, is the lack of intraluminal pressure and flow in the vessels being studied. Moreover, differences in basal vascular tone have led to varied interpretations regarding the polarity of vascular responses following neuron-to-glial stimulation. Given the complexity of astrocyte-induced neurovascular responses, we propose the use of a modified in vitro brain slice preparation, where intraluminal arteriolar pressure and flow are retained. Throughout this review, we discuss the advantages and disadvantages to be considered when using brain slices for neurovascular studies. Potential ways to overcome the current limitations are proposed.
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