ArticleNature genetics2010
The ratio of human X chromosome to autosome diversity is positively correlated with genetic distance from genes.
Article in Nature genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Structural diversity and evolutionary constraints of oxidative phosphorylation.Cell genomics · 2025Article
- Genomic and demographic processes differentially influence genetic variation across the human X chromosome.PloS one · 2023Article
- Substantial but Misunderstood Human Sexual Dimorphism Results Mainly From Sexual Selection on Males and Natural Selection on Females.Frontiers in psychology · 2022Article
- Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome.PLoS genetics · 2021Article
- How Good Are Predictions of the Effects of Selective Sweeps on Levels of Neutral Diversity?Genetics · 2020Article
- Changes in life history and population size can explain the relative neutral diversity levels on X and autosomes in extant human populations.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Complex patterns of sex-biased demography in canines.Proceedings. Biological sciences · 2019Article
- The Role of Phylogenetically Conserved Elements in Shaping Patterns of Human Genomic Diversity.Molecular biology and evolution · 2018Article
- Human demographic history has amplified the effects of background selection across the genome.PLoS genetics · 2018Article
- Genetic Diversity on the Sex Chromosomes.Genome biology and evolution · 2018Review
- Contrasting Patterns of Genomic Diversity Reveal Accelerated Genetic Drift but Reduced Directional Selection on X-Chromosome in Wild and Domestic Sheep Species.Genome biology and evolution · 2018Article
- Article
- The fire ant social chromosome supergene variant Sb shows low diversity but high divergence from SB.Molecular ecology · 2017Article
- Variable Autosomal and X Divergence Near and Far from Genes Affects Estimates of Male Mutation Bias in Great Apes.Genome biology and evolution · 2016Article
- Explosive genetic evidence for explosive human population growth.Current opinion in genetics & development · 2016Review
- Determinants of genetic diversity.Nature reviews. Genetics · 2016Review
- The Genetic Cost of Neanderthal Introgression.Genetics · 2016Article
- Targeted capture in evolutionary and ecological genomics.Molecular ecology · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ratio of X-linked to autosomal diversity was estimated from an analysis of six human genome sequences and found to deviate from the expected value of 0.75. However, the direction of this deviation depends on whether a particular sequence is close to or far from the nearest gene. This pattern may be explained by stronger locally acting selection on X-linked genes compared with autosomal genes, combined with larger effective population sizes for females than for males.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.