ArticleNature genetics2010
Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.
Article in Nature genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 15 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
153 citing papers in PubMed, 15 syntheses or guidelines pooled it, 405 citations in OpenAlex.
- A multi-ancestry meta genome-wide association study of migraine among veterans: associations with traumatic brain injury, depression, and post-traumatic stress disorder.Molecular psychiatry · 2026Pooled it
- Fine-mapping a genome-wide meta-analysis of 98,374 migraine cases identifies 181 sets of candidate causal variants.Nature communications · 2026Pooled it
- What does a migraine aura look like?-A systematic review.The journal of headache and pain · 2025Pooled it
- The 200 most influential publications in migraine research: a bibliometric mapping of the intellectual landscape.Frontiers in neurology · 2025Pooled it
- Current Update on Categorization of Migraine Subtypes on the Basis of Genetic Variation: a Systematic Review.Molecular neurobiology · 2024Pooled it
- Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.Nature genetics · 2022Pooled it
- Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses.The journal of headache and pain · 2020Pooled it
- Quantitative assessment of the association betweenBioscience reports · 2018Pooled it
- The association between brain-derived neurotrophic factor gene polymorphism and migraine: a meta-analysis.The journal of headache and pain · 2017Pooled it
- Grey matter alterations in migraine: A systematic review and meta-analysis.NeuroImage. Clinical · 2017Pooled it
- Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.Nature genetics · 2016Pooled it
- Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants.Neurology · 2015Pooled it
- Genome-wide meta-analysis identifies new susceptibility loci for migraine.Nature genetics · 2013Pooled it
- Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis.Cephalalgia : an international journal of headache · 2011Pooled it
- Meta-analysis of genome-wide association for migraine in six population-based European cohorts.European journal of human genetics : EJHG · 2011Pooled it
- Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura.Cephalalgia : an international journal of headache · 2013Trial
- Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis.Dialogues in clinical neuroscience · 2026Article
- Mapping structural and functional brain networks associated with migraine.The journal of headache and pain · 2026Article
- Article
- Unmasking the relationship between CGRP and glutamate: from peripheral excitation to central sensitization in migraine.The journal of headache and pain · 2025Review
93 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
66 authors at 20 institutions in 14 countries.
Funding
Abstract
Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (P = 5.38 × 10⁻⁹, odds ratio = 1.23, 95% CI 1.150-1.324) in a genome-wide association study of 2,731 migraine cases ascertained from three European headache clinics and 10,747 population-matched controls. The association was replicated in 3,202 cases and 40,062 controls for an overall meta-analysis P value of 1.69 × 10⁻¹¹ (odds ratio = 1.18, 95% CI 1.127-1.244). rs1835740 is located between MTDH (astrocyte elevated gene 1, also known as AEG-1) and PGCP (encoding plasma glutamate carboxypeptidase). In an expression quantitative trait study in lymphoblastoid cell lines, transcript levels of the MTDH were found to have a significant correlation to rs1835740 (P = 3.96 × 10⁻⁵, permuted threshold for genome-wide significance 7.7 × 10⁻⁵. To our knowledge, our data establish rs1835740 as the first genetic risk factor for migraine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.