ArticleCarcinogenesis2010
DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer.
Article in Carcinogenesis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Heterogeneity Analysis of Bladder Cancer Based on DNA Methylation Molecular Profiling.Frontiers in oncology · 2022Article
- Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence.International journal of inflammation · 2019Review
- Breast tumor DNA methylation patterns associated with smoking in the Carolina Breast Cancer Study.Breast cancer research and treatment · 2017Article
- Identifying Etiologically Distinct Sub-Types of Cancer: A Demonstration Project Involving Breast Cancer.Cancer medicine · 2015Article
- Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling.Epigenetics · 2015Review
- Integrative epigenomic analysis of differential DNA methylation in urothelial carcinoma.Genome medicine · 2015Article
- Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity.Nature reviews. Cancer · 2015Review
- Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- DNA methylation analyses of urothelial carcinoma reveal distinct epigenetic subtypes and an association between gene copy number and methylation status.Epigenetics · 2012Article
- Emerging critical role of molecular testing in diagnostic genitourinary pathology.Archives of pathology & laboratory medicine · 2012Review
- Hypermethylation in bladder cancer: biological pathways and translational applications.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Article
- Global hypomethylation identifies Loci targeted for hypermethylation in head and neck cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma.Epigenetics · 2011Article
- Epigenomics in environmental health.Frontiers in genetics · 2011Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
DNA methylation profiles can be used to define molecular cancer subtypes that may better inform disease etiology and clinical decision-making. This investigation aimed to create DNA methylation profiles of bladder cancer based on CpG methylation from almost 800 cancer-related genes and to then examine the relationship of those profiles with exposures related to risk and clinical characteristics. DNA, derived from formalin-fixed paraffin-embedded tumor samples obtained from incident cases involved in a population-based case-control study of bladder cancer in New Hampshire, was used for methylation profiling on the Illumina GoldenGate Methylation Bead Array. Unsupervised clustering of those loci with the greatest change in methylation between tumor and non-diseased tissue was performed to defined molecular subgroups of disease, and univariate tests of association followed by multinomial logistic regression was used to examine the association between these classes, bladder cancer risk factors and clinical phenotypes. Membership in the two most methylated classes was significantly associated with invasive disease (P < 0.001 for both class 3 and 4). Male gender (P = 0.04) and age >70 years (P = 0.05) was associated with membership in one of the most methylated classes. Finally, average water arsenic levels in the highest percentile predicted membership in an intermediately methylated class of tumors (P = 0.02 for both classes). Exposures and demographic associated with increased risk of bladder cancer specifically associate with particular subgroups of tumors defined by DNA methylation profiling and these subgroups may define more aggressive disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.