ArticleAmerican journal of respiratory and critical care medicine2011
Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth.
Article in American journal of respiratory and critical care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Characteristics of cohort studies of long-term exposure to PMEnvironmental science and pollution research international · 2019Pooled it
- Plasma advanced oxidative protein products are associated with anti-oxidative stress pathway genes and malaria in a longitudinal cohort.Malaria journal · 2014Trial
- The Link between Type 2 Diabetes Mellitus and the Polymorphisms of Glutathione-Metabolizing Genes Suggests a New Hypothesis Explaining Disease Initiation and Progression.Life (Basel, Switzerland) · 2021Article
- Air pollution and lung function in children.The Journal of allergy and clinical immunology · 2021Review
- Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations.Chronic diseases and translational medicine · 2021Review
- The Respiratory Risks of Ambient/Outdoor Air Pollution.Clinics in chest medicine · 2020Review
- Review
- Effect of inhaled allergens and air pollutants on childhood rhinitis development.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Article
- Quantile Regression Analysis of the Distributional Effects of Air Pollution on Blood Pressure, Heart Rate Variability, Blood Lipids, and Biomarkers of Inflammation in Elderly American Men: The Normative Aging Study.Environmental health perspectives · 2016Article
- Particulate air pollution and impaired lung function.F1000Research · 2016Review
- Modification of the association between PM10 and lung function decline by cadherin 13 polymorphisms in the SAPALDIA cohort: a genome-wide interaction analysis.Environmental health perspectives · 2015Article
- Environmental effects on immune responses in patients with atopy and asthma.The Journal of allergy and clinical immunology · 2014Review
- Therapeutic effect of daphnetin on the autoimmune arthritis through demethylation of proapoptotic genes in synovial cells.Journal of translational medicine · 2014Article
- Possible molecular mechanisms linking air pollution and asthma in children.BMC pulmonary medicine · 2014Review
- Effect of GSTM2-5 polymorphisms in relation to tobacco smoke exposures on lung function growth: a birth cohort study.BMC pulmonary medicine · 2013Article
- Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort.Environmental health perspectives · 2013Article
- Selection of genes for gene-environment interaction studies: a candidate pathway-based strategy using asthma as an example.Environmental health : a global access science source · 2013Article
- PM2.5, oxidant defence and cardiorespiratory health: a review.Environmental health : a global access science source · 2013Review
- Low level maternal smoking and infant birthweight reduction: genetic contributions of GSTT1 and GSTM1 polymorphisms.BMC pregnancy and childbirth · 2012Article
- Air pollution and health: emerging information on susceptible populations.Air quality, atmosphere, & health · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
rationaleGlutathione plays an important role in antioxidant and inflammatory processes in the lung. Alterations in glutathione metabolism are a central feature of several chronic lung diseases.
objectivesTo determine whether sequence variation in genes in the glutathione synthesis pathway alters susceptibility to air pollution effects on lung function.
methodsIn this prospective study, 14,821 lung function measurements were taken on 2,106 children from 12 Southern California cities. Tagging single-nucleotide polymorphisms in glutathione metabolism pathway genes GSS, GSR, GCLM, and GCLC were genotyped by GoldenGate assay (Illumina, San Diego, CA). Mixed regression models were used to determine whether particular haplotypes were associated with FEV(1), maximal mid-expiratory flow rate, and FVC and whether any of the genetic associations varied with levels of exposure to air pollutants. MEASUREMENTS AND MAIN
resultsWe found that variation in the GSS locus was associated with differences in susceptibility of children for lung function growth deficits associated with NO(2), PM(10), PM(2.5), elemental carbon, organic carbon, and O(3). The negative effects of air pollutants were largely observed within participants who had a particular GSS haplotype. The effects ranged from -124.2 to -149.1 for FEV(1), from -92.9 to -126.7 for FVC, and from -193.9 to -277.9 for maximal mid-expiratory flow rate for all pollutants except O(3), which showed a larger decrease in lung function in children without this haplotype.
conclusionsVariation in GSS was associated with differences in susceptibility to adverse effects of pollutants on lung function growth.
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